Evidence map›Paper›PMID 38706850›Full record

ArticleiScience2024

Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition.

Jennifer A Hurcombe, Fern Barrington, Micol Marchetti, Virginie M S Betin, Emily E Bowen, Abigail C Lay, Lan Ni, Lusyan Dayalan, Robert J P Pope, Paul T Brinkkoetter and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jennifer A HurcombeBristol Renal, University of Bristol, Bristol, UK.
Fern BarringtonBristol Renal, University of Bristol, Bristol, UK.
Micol MarchettiBristol Renal, University of Bristol, Bristol, UK.
Virginie M S BetinBristol Renal, University of Bristol, Bristol, UK.
Emily E BowenBristol Renal, University of Bristol, Bristol, UK.
Abigail C LayBristol Renal, University of Bristol, Bristol, UK.
Lan NiBristol Renal, University of Bristol, Bristol, UK.
Lusyan DayalanBristol Renal, University of Bristol, Bristol, UK.
Robert J P PopeBristol Renal, University of Bristol, Bristol, UK.
Paul T BrinkkoetterDepartment II of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Martin HolzenbergerSorbonne University, INSERM, Paris, France.
Gavin I WelshBristol Renal, University of Bristol, Bristol, UK.
Richard J M CowardBristol Renal, University of Bristol, Bristol, UK.

Funding

Medical Research Council MR/K010492/1Medical Research Council MR/T002263/1
6 · The paper itself

Abstract

Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout of the closely related insulin-like growth factor 1 receptor (IGF1R) in podocytes is detrimental, resulting in albuminuria

Indexed as

biological sciencescell biologyMolecular biology

Identifiers

PMID38706850
PMCPMC11068853

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.