Evidence map›Paper›PMID 38706841›Full record

ArticleiScience2024

Fasting-induced RNF152 resensitizes gallbladder cancer cells to gemcitabine by inhibiting mTORC1-mediated glycolysis.

Ying Tao, Zijun Gong, Sheng Shen, Yaqi Ding, Rui Zan, Bohao Zheng, Wentao Sun, Chaolin Ma, Mengxuan Shu, Xiao Lu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ying TaoDepartment of General Surgery, Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Fudan University, Shanghai, China.
Zijun GongDepartment of Biliary Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Sheng ShenDepartment of Biliary Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yaqi DingRuijin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine Central Laboratory, Shanghai, China.
Rui ZanDepartment of Biliary Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Bohao ZhengDepartment of Biliary Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Wentao SunDepartment of Biliary Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Chaolin MaDepartment of Biliary Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Mengxuan ShuDepartment of Biliary Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiao LuDepartment of Biliary Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Han LiuDepartment of Biliary Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiaoling NiDepartment of Biliary Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Houbao LiuDepartment of General Surgery, Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Fudan University, Shanghai, China.
Tao SuoDepartment of Biliary Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal mTORC1 activation by the lysosomal Ragulator complex has been implicated in cancer and glycolytic metabolism associated with drug resistance. Fasting upregulates RNF152 and mediates the metabolic status of cells. We report that RNF152 regulates mTORC1 signaling by targeting a Ragulator subunit, p18, and attenuates gemcitabine resistance in gallbladder cancer (GBC). We detected levels of RNF152 and p18 in tissues and undertook mechanistic studies using activators, inhibitors, and lentivirus transfections. RNF152 levels were significantly lower in GBC than in adjacent non-cancer tissues. Fasting impairs glycolysis, induces gemcitabine sensitivity, and upregulates RNF152 expression. RNF152 overexpression increases the sensitivity of GBC cells to gemcitabine, whereas silencing RNF152 has the opposite effect. Fasting-induced RNF152 ubiquitinates p18, resulting in proteasomal degradation. RNF152 deficiency increases the lysosomal localization of p18 and increases mTORC1 activity, to promote glycolysis and decrease gemcitabine sensitivity. RNF152 suppresses mTORC1 activity to inhibit glycolysis and enhance gemcitabine sensitivity in GBC.

Indexed as

CancerCell biologyMolecular biology

Identifiers

PMID38706841
PMCPMC11068552

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.