Continuous and bilevel positive airway pressure may improve radiotherapy delivery in patients with intra-thoracic tumors.

J Elshof, C M Steenstra, A G H Niezink, P J Wijkstra, R Wijsman, M L Duiverman

Abstract read

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Article in Clinical and translational radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Radiation-Associated Heart Disease in Korean Women after Radiotherapy for Breast Cancer: Insights from the National Health Insurance Service Database.Cancer research and treatment · 2026
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5 · Who and what money

Authors and funding

6 authors.

J ElshofDepartment of Pulmonary Diseases/Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

C M SteenstraDepartment of Pulmonary Diseases/Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

A G H NiezinkDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

P J WijkstraDepartment of Pulmonary Diseases/Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

R WijsmanDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

M L DuivermanDepartment of Pulmonary Diseases/Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Minimizing tumor motion in radiotherapy for intra-thoracic tumors reduces side-effects by limiting radiation exposure to healthy tissue. Continuous or Bilevel Positive Airway Pressure (CPAP/BiPAP) could achieve this, since it could increase lung inflation and decrease tidal volume variability. We aim to identify the better CPAP/BiPAP setting for minimizing tumor motion. Methods: In 10 patients (5 with lung cancer, 5 with other intra-thoracic tumors), CPAP/BiPAP was tested with the following settings for 10 min each: CPAP 5, 10 and 15 cmH Results: Nine out of ten patients tolerated all settings; one patient could not sustain CPAP-15. A significant difference in EELI was observed between settings (χ Conclusions: This study shows that the application of different settings of CPAP/BiPAP in patients with intra-thoracic tumors is feasible and tolerable. BiPAP with a higher BURR may offer the greatest potential for mitigating tumor motion among the applied settings, although further research investigating tumor motion should be conducted.

Indexed as

BiPAPCPAPNon-invasive ventilationRadiotherapy

Identifiers

PMID38706725

DOI10.1016/j.ctro.2024.100784

PMCPMC11063599

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