Evidence map›Paper›PMID 38706638›Full record

ArticlePattern recognition2024

Assessment of Volumetric Dense Tissue Segmentation in Tomosynthesis Using Deep Virtual Clinical Trials.

B Barufaldi, J V Gomes, Tm Silva Filho, T G do Rêgo, Y Malheiros, T L Vent, A Gastounioti, Ada Maidment

Abstract read
In one paragraph

Article in Pattern recognition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

B BarufaldiDepartment of Radiology, University of Pennsylvania, 3640 Hamilton Walk, PA 19104, United States.
J V GomesCenter of Informatics, Federal University of Paraíba, Rua dos Escoteiros s/n, João Pessoa, PB 58058-600, Brazil.
Tm Silva FilhoDepartment of Statistics, Federal University of Paraíba, Campus I - Jardim Cidade Universitária, João Pessoa - PB, 58051-090, Brazil.
T G do RêgoCenter of Informatics, Federal University of Paraíba, Rua dos Escoteiros s/n, João Pessoa, PB 58058-600, Brazil.
Y MalheirosCenter of Informatics, Federal University of Paraíba, Rua dos Escoteiros s/n, João Pessoa, PB 58058-600, Brazil.
T L VentDepartment of Radiology, University of Pennsylvania, 3640 Hamilton Walk, PA 19104, United States.
A GastouniotiDepartment of Radiology, University of Pennsylvania, 3640 Hamilton Walk, PA 19104, United States.
Ada MaidmentDepartment of Radiology, University of Pennsylvania, 3640 Hamilton Walk, PA 19104, United States.

Funding

Advancing breast cancer risk assessment with digital breast tomosynthesisR01CA286120 · NCI · WASHINGTON UNIVERSITY · PI Aimilia Gastounioti · 2024 to 2026
$3.1M
Visual Search in 3D Medical Imaging ModalitiesR01EB026427 · NIBIB · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Miguel Patricio Eckstein · 2018 to 2026
$2.5M
Virtual Clinical Trials: Simulation of Digital Breast Tomosynthesis ScreeningR01CA154444 · NCI · UNIVERSITY OF PENNSYLVANIA · PI MAIDMENT, ANDREW DOUGLAS ARNOLD · 2011 to 2014
$2.3M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
Assessment of medical image quality with foveated search modelsR01EB018958 · NIBIB · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ECKSTEIN, MIGUEL PATRICIO · 2015 to 2018
$1.7M
NCI NIH HHS R01 CA154444NCI NIH HHS R01 CA286120NIBIB NIH HHS R01 EB018958NIBIB NIH HHS R01 EB026427NIH HHS S10 OD023495
6 · The paper itself

Abstract

The adoption of artificial intelligence (AI) in medical imaging requires careful evaluation of machine-learning algorithms. We propose the use of a "deep virtual clinical trial" (DeepVCT) method to effectively evaluate the performance of AI algorithms. In this paper, DeepVCTs have been proposed to elucidate limitations of AI applications and predictions of clinical outcomes, avoiding biases in study designs. The DeepVCT method was used to evaluate the performance of nnU-Net models in assessing volumetric breast density (VBD) from digital breast tomosynthesis (DBT) images. In total, 2,010 anatomical breast models were simulated. Projections were simulated using the acquisition geometry of a clinical DBT system. The projections were reconstructed using 0.1, 0.2, and 0.5 mm plane spacing. nnU-Net models were developed using the center-most planes of the reconstructions with the respective ground-truth. The results show that the accuracy of the nnU-Net improves significantly with DBT images reconstructed with 0.1 mm plane spacing (78.4×205.3×40.1 mm

Identifiers

PMID38706638
PMCPMC11065113

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.