Evidence map›Paper›PMID 38706522›Full record

ArticleBone reports2024

Long-duration leptin transgene expression in dorsal vagal complex does not alter bone parameters in female Sprague Dawley rats.

Russell T Turner, Adam J Branscum, Urszula T Iwaniec

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Russell T TurnerSkeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA.
Adam J BranscumBiostatistics Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA.
Urszula T IwaniecSkeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA.

Funding

The Role of Leptin in Inflammation-Driven Bone LossR01AR060913 · NIAMS · OREGON STATE UNIVERSITY · PI IWANIEC, URSZULA T · 2011 to 2025
$3.5M
NPY AND APPETITE--CELLULAR AND MOLECULAR BASISR01DK037273 · NIDDK · UNIVERSITY OF FLORIDA · PI KALRA, SATYA P · 1986 to 2005
$1.9M
NEUROTOXINS, NEURAL INJURY, AND OBESITYR01NS032727 · NINDS · UNIVERSITY OF FLORIDA · PI KALRA, PUSHPA S. · 1995 to 2003
$1.1M
NIAMS NIH HHS R01 AR060913NIDDK NIH HHS R01 DK037273NINDS NIH HHS R01 NS032727
6 · The paper itself

Abstract

The hypothalamus and dorsal vagal complex (DVC) are both important for integration of signals that regulate energy balance. Increased leptin transgene expression in either the hypothalamus or DVC of female rats was shown to decrease white adipose tissue and circulating levels of leptin and adiponectin. However, in contrast to hypothalamus, leptin transgene expression in the DVC had no effect on food intake, circulating insulin, ghrelin and glucose, nor on thermogenic energy expenditure. These findings imply different roles for hypothalamus and DVC in leptin signaling. Leptin signaling is required for normal bone accrual and turnover. Leptin transgene expression in the hypothalamus normalized the skeletal phenotype of leptin-deficient

Indexed as

BoneDorsal vagal complexHistomorphometryHypothalamusLeptinMicrocomputed tomography

Identifiers

PMID38706522
PMCPMC11067478

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.