Evidence map›Paper›PMID 38706352›Full record

ArticleCurrent drug delivery2025

A Biodegradable Nano-Drug Delivery Platform for Co-Delivery of Minocycline and Chitosan to Achieve Efficient and Safe Non-Surgical Periodontitis Therapy.

Jinxin Yang, Jie Mou, Kexin Ding, Shaoyue Zhu, Zhe Sun, Yawen Cui, Sihan Meng, Guowei Qiang, Weisen Zhong, Zongxiang Liu

Abstract read
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In one paragraph

Article in Current drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinxin YangSchool of stomatology, Xuzhou Medical University, 221000, Xuzhou, China.
Jie MouSchool of stomatology, Xuzhou Medical University, 221000, Xuzhou, China.
Kexin DingSchool of stomatology, Xuzhou Medical University, 221000, Xuzhou, China.
Shaoyue ZhuThe Affiliated Stomatological Hospital of Xuzhou Medical University, 221000, Xuzhou, China.
Zhe SunSchool of stomatology, Xuzhou Medical University, 221000, Xuzhou, China.
Yawen CuiSchool of stomatology, Xuzhou Medical University, 221000, Xuzhou, China.
Sihan MengJiangsu Key Laboratory of New drug and Clinical Pharmacy, Xuzhou Medical College, Xuzhou, 221006, China.
Guowei QiangSchool of stomatology, Xuzhou Medical University, 221000, Xuzhou, China.
Weisen ZhongJiangsu Key Laboratory of New drug and Clinical Pharmacy, Xuzhou Medical College, Xuzhou, 221006, China.
Zongxiang LiuSchool of stomatology, Xuzhou Medical University, 221000, Xuzhou, China.

Funding

Xuzhou's key research and development plan (social development China) project KC22102
6 · The paper itself

Abstract

introductionMesoporous silica nanoparticles (MSN) are widely used as ideal nanovehicles for the delivery of chemotherapeutic drugs. However, the balance between high anti-periodontitis activity and low biotoxicity has been challenging to maintain in most relevant studies owing to the slow degradation of silica in living organisms.

methodIn this study, responsive hydroxyapatite (HAP) was doped into the MSN skeleton, and the chemotherapeutic drug minocycline hydrochloride (MH) was loaded into the pores of MSN, forming a negatively charged drug delivery system. Cationic chitosan (COS) is a biodegradable material with high antibacterial performance and good biosafety. In this study, COS was immobilized on the surface of the drug-loaded particles through stable charge interaction to construct a composite drug delivery system (MH@MSNion@COS).

resultsIn vitro and cellular experiments demonstrated effective degradation of the nanocarrier system and synchronized controlled release of the drug. Notably, compared with single MH administration, this system, in which MH and COS jointly regulated the expression levels of periodontitis- associated inflammatory factors (TNF-α, IL-6, IL-1β, and iNOS), better inhibited the progress of periodontitis and induced tissue regeneration without showing significant toxic side effects in cells.

conclusionThis system provides a promising strategy for the design of intelligent, efficient, and safe anti-periodontitis drug delivery systems.

Indexed as

Anti-Bacterial AgentsChitosanMinocyclineNanoparticle Drug Delivery SystemNanoparticlesPeriodontitisAnimalsDrug CarriersDrug Delivery SystemsDrug LiberationDurapatiteHumansMiceSilicon DioxideAnti-Bacterial AgentsChitosanDrug CarriersDurapatiteMinocyclineNanoparticle Drug Delivery SystemSilicon Dioxideantibacterialbiodegradationbone formationin vitro cytotoxicity.Mesoporous silica nanoparticleperiodontitis therapy

Identifiers

PMID38706352

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.