ArticleThe American journal of psychiatry2024
Predictors of Substance Use Initiation by Early Adolescence.
Article in The American journal of psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Polysubstance use disorders among US adults.Molecular psychiatry · 2026Article
- Untangling relationships between cognitive development and child and adolescent mental health: Findings from the ABCD Study.Developmental cognitive neuroscience · 2026Review
- From school climate to brain development: What the ABCD study reveals about the educational context of adolescence.Developmental cognitive neuroscience · 2026Review
- Longitudinal neurocognitive trajectories in a large cohort of youth who use cannabis: combining self-report and toxicology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Associations Between Youth Marijuana and Alcohol Use, Neurocognitive Performance, and Triple-Network Resting-State Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Connectome-based predictive modeling of concurrent and longitudinal substance use vulnerability in adolescence.Developmental cognitive neuroscience · 2026Article
- Risk calculation circuit abnormalities plus psychosocial risk variables predict problematic substance use in youth with externalizing disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Parallel Contributions of Externalizing Polygenic Liability and Brain Imaging Phenotypes to Adolescent Substance Use Initiation Timing: A Multistage Analysis in the ABCD Study.bioRxiv : the preprint server for biology · 2026Article
- A Machine Learning Based Causal Interface for Time Varying Environmental Predictors of Substance Use Initiation in the ABCD Study.medRxiv : the preprint server for health sciences · 2026Article
- Dynamic and Baseline Multi-Task Learning for Predicting Substance Use Initiation in the ABCD Study.medRxiv : the preprint server for health sciences · 2026Article
- The Brain Age Gap as a Predictor of Alcohol Initiation in Adolescence.bioRxiv : the preprint server for biology · 2026Article
- Longitudinal Neurocognitive Trajectories in a Large Cohort of Youth Who Use Cannabis: Combining Self-Report and Toxicology.bioRxiv : the preprint server for biology · 2026Article
- Review of Risk Factors for Opioid Misuse and Addiction Following Traumatic Injury.Healthcare (Basel, Switzerland) · 2026Review
- Brain network features predating early alcohol initiation in adolescence.Translational psychiatry · 2026Article
- Impulsivity-related predictors of adolescent substance use initiation.Psychological medicine · 2026Article
- Parents' perceptions of substance use prevention programs for adolescents in private schools in Chile: a qualitative study.Substance abuse treatment, prevention, and policy · 2026Article
- Psychosocial risk for substance use in 80,000 Mexican undergraduates: mental health and academic strain.Frontiers in public health · 2026Article
- Neurobehavioral correlates of inhibitory control in youth at-risk for early low-level alcohol use initiation: neuroimaging findings from the ABCD study.Frontiers in psychiatry · 2026Article
- Environmental, Health, and Psychological Factors Predict Alcohol Sipping in Childhood: A Machine Learning Analysis of the ABCD Study.JAACAP open · 2025Article
- The mesocorticolimbic system in stimulant use disorder.Molecular psychiatry · 2025Review
Corrections and comments
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Authors and funding
11 authors.
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Abstract
objectiveSubstance use initiation during early adolescence is associated with later development of substance use and mental health disorders. This study used various domains to predict substance use initiation, defined as trying any nonprescribed substance (e.g., alcohol, tobacco, cannabis), by age 12, using a large longitudinal data set.
methodsSubstance-naive youths from the Adolescent Brain Cognitive Development Study (ages 9-10; N=6,829) were followed for 3 years. A total of 420 variables were examined as predictors of substance use initiation, using a penalized logistic regression with elastic net; domains spanned demographic characteristics, self and peer involvement with substance use, parenting behaviors, mental and physical health, culture and environment, hormones, neurocognitive functioning, and structural neuroimaging.
resultsBy age 12, 982 (14.4%) children reported substance initiation, with alcohol being the most common. Models with only self-report predictors had similar prediction performance to models adding hormones, neurocognitive factors, and neuroimaging predictors (AUC
conclusionsSociodemographic variables were the most robust predictors of substance use initiation. Adding resource-intensive measures, including hormones, neurocognitive assessment, and structural neuroimaging, did not improve prediction of substance use initiation. The application of these large-scale findings in clinical settings could help to streamline and tailor prevention and early intervention efforts.
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