Evidence map›Paper›PMID 38705966›Full record

ArticleActa neuropathologica2024

Sex differences in the extent of acute axonal pathologies after experimental concussion.

Hailong Song, Alexandra Tomasevich, Andrew Paolini, Kevin D Browne, Kathryn L Wofford, Brian Kelley, Eashwar Kantemneni, Justin Kennedy, Yue Qiu, Andrea L C Schneider and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hailong SongDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA.
Alexandra TomasevichDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA.
Andrew PaoliniDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA.
Kevin D BrowneDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA.
Kathryn L WoffordDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA.
Brian KelleyDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA.
Eashwar KantemneniDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA.
Justin KennedyDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA.
Yue QiuDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA.
Andrea L C SchneiderDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jean-Pierre DolleDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA.
D Kacy CullenDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA.
Douglas H SmithDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA. smithdou@pennmedicine.upenn.edu.

Funding

Data Coordinating CoreU54NS115322 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SMITH, DOUGLAS HAMILTON · 2019 to 2023
$9.2M
TBI: Uncovering Mechanisms of AD-like pathologyR01NS038104 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SMITH, DOUGLAS HAMILTON · 1999 to 2020
$7.6M
Neuropathological Characterization of 'CTE'R01NS094003 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Douglas Hamilton Smith, William Stewart · 2016 to 2026
$5.1M
Detection and Mechanisms of Mild Traumatic Brain InjuryR01NS092398 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SMITH, DOUGLAS HAMILTON · 2015 to 2019
$1.9M
Establishing Mechanisms Between Traumatic Brain Injury and Dementia Using Epidemiology, Clinical Studies, Blood-Based Biomarkers, and Neuroimaging BiomarkersK23NS123340 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Andrea Lauren Christman Schneider · 2022 to 2026
$1.1M
Molecular Mechanisms and Treatment of Diffuse Axonal InjuryK08NS110929 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KELLEY, BRIAN J. · 2019 to 2024
$889k
Understanding and Controlling Neuro-immune Interactions Following Traumatic Brain InjuryR00NS125039 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Kathryn Leigh Wofford · 2024 to 2026
$747k
Understanding and Controlling Neuro-immune Interactions Following Traumatic Brain InjuryK99NS125039 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI WOFFORD, KATHRYN LEIGH · 2022 to 2023
$220k
Alzheimer's Association AARFD-23-1144656NIH HHS K08NS110929NIH HHS R01NS038104NIH HHS R01NS092398NIH HHS R01NS094003NIH HHS U54NS115322NINDS NIH HHS K08 NS110929NINDS NIH HHS K23 NS123340NINDS NIH HHS K99 NS125039NINDS NIH HHS R00 NS125039NINDS NIH HHS R01 NS038104NINDS NIH HHS R01 NS092398NINDS NIH HHS R01 NS094003NINDS NIH HHS U54 NS115322
6 · The paper itself

Abstract

Although human females appear be at a higher risk of concussion and suffer worse outcomes than males, underlying mechanisms remain unclear. With increasing recognition that damage to white matter axons is a key pathologic substrate of concussion, we used a clinically relevant swine model of concussion to explore potential sex differences in the extent of axonal pathologies. At 24 h post-injury, female swine displayed a greater number of swollen axonal profiles and more widespread loss of axonal sodium channels than males. Axon degeneration for both sexes appeared to be related to individual axon architecture, reflected by a selective loss of small caliber axons after concussion. However, female brains had a higher percentage of small caliber axons, leading to more extensive axon loss after injury compared to males. Accordingly, sexual dimorphism in axonal size is associated with more extensive axonal pathology in females after concussion, which may contribute to worse outcomes.

Indexed as

AxonsBrain ConcussionDisease Models, AnimalSex CharacteristicsAnimalsBrainFemaleMaleSwineAmyloid precursor proteinAxon ultrastructureConcussionDiffuse axonal injurySex differenceVoltage-gated sodium channel isoform 1.6

Identifiers

PMID38705966
PMCPMC11070329

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.