Evidence map›Paper›PMID 38705963›Full record

ArticleBiotechnology letters2024

Regulation of fadR on the ROS defense mechanism in Shewanalla oneidensis.

Qiu Meng, Yinming Xu, Liming Dai, Xuzhe Ge, Pei Qiao

Abstract read
PubMed Publisher
In one paragraph

Article in Biotechnology letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qiu MengCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.ORCID http://orcid.org/0000-0003-4377-9395
Yinming XuCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.
Liming DaiCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.
Xuzhe GeCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.
Pei QiaoCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China. peiq@zjut.edu.cn.ORCID http://orcid.org/0000-0002-4210-4727

Funding

Basic Public Welfare Research Program of Zhejiang Province LQ23C010003National Natural Science Foundation of China 32300018
6 · The paper itself

Abstract

Protein FadR is known as a fatty acid metabolism global regulator that sustains cell envelope integrity by changing the profile of fatty acid. Here, we present its unique participation in the defense against reactive oxygen species (ROS) in the bacterium. FadR contributes to defending extracellular ROS by maintaining the permeability of the cell membrane. It also facilitates the ROS detoxification process by increasing the expression of ROS neutralizers (KatB, KatG, and AhpCF). FadR also represses the leakage of ROS by alleviating the respiratory action conducted by terminal cytochrome cbb3-type heme-copper oxidases (ccoNOQP). These findings suggest that FadR plays a comprehensive role in modulating the bacterial oxidative stress response, instead of merely strengthening the cellular barrier against the environment. This study sheds light on the complex mechanisms of bacterial ROS defense and offers FadR as a novel target for ROS control research.

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialOxidative StressReactive Oxygen SpeciesCell MembraneBacterial ProteinsReactive Oxygen SpeciesCell membraneFadRRespiratory actionROS detoxificationTerminal oxidase

Identifiers

PMID38705963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.