Evidence map›Paper›PMID 38705911›Full record

ArticleHistochemistry and cell biology2024

Differential expression of small bowel TGFβ1 and TGFβ3 characterizes intestinal strictures in patients with fibrostenotic Crohn's disease.

Steven Levitte, Ibaad Khan, Violet Iyahen, James Ziai, John Gubatan, Rebecca Sheng, Sara B Glickstein, Tianhe Sun, K T Park, Jacqueline McBride and 1 more

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Article in Histochemistry and cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. In focus in HCB.Histochemistry and cell biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Steven LevitteDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University, 750 Welch Rd Ste 116, Palo Alto, CA, 94304, USA. slevitte@stanford.edu.
Ibaad KhanMorehouse School of Medicine, Atlanta, GA, USA.
Violet IyahenMorehouse School of Medicine, Atlanta, GA, USA.
James ZiaiGenentech, Inc, South San Francisco, CA, USA.
John GubatanDivision of Gastroenterology and Hepatology, Stanford University, Palo Alto, CA, USA.
Rebecca ShengGenentech, Inc, South San Francisco, CA, USA.
Sara B GlicksteinGenentech, Inc, South San Francisco, CA, USA.
Tianhe SunGenentech, Inc, South San Francisco, CA, USA.
K T ParkGenentech, Inc, South San Francisco, CA, USA.
Jacqueline McBrideGenentech, Inc, South San Francisco, CA, USA.
Mary KeirGenentech, Inc, South San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small bowel strictures remain a debilitating consequence of Crohn's disease and contribute to poor outcomes for patients. Recently, TGFβ has been identified as an important driver of intestinal fibrosis. We studied the localization of TGFβ isoforms in ileal strictures of patients with Crohn's disease using in situ hybridization to understand TGFβ's role in stricture formation. The mucosa of strictures was characterized by higher TGFβ1 while the stricture submucosa showed higher TGFβ3 compared to normal ileum from patients without Crohn's disease (p = 0.02 and p = 0.044, respectively). We correlated these findings with single-cell transcriptomics which demonstrated that TGFβ3 transcripts overall are very rare, which may partially explain why its role in intestinal fibrosis has remained unclear to date. There were no significant differences in fibroblast or B cell TGFβ1 and/or TGFβ3 expression in inflamed vs. noninflamed ileum. We discuss the implications of these findings for therapeutic development strategies to treat patients with fibrostenotic Crohn's disease.

Indexed as

Crohn DiseaseFibrosisTransforming Growth Factor beta1Transforming Growth Factor beta3AdultConstriction, PathologicFemaleHumansIleumIntestine, SmallMaleMiddle AgedTGFB1 protein, humanTGFB3 protein, humanTransforming Growth Factor beta1Transforming Growth Factor beta3Inflammatory bowel diseaseIntestinal fibrosisTGFβ

Identifiers

PMID38705911

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.