Evidence map›Paper›PMID 38704841›Full record

ArticleThe Journal of physiology2024

Loss of anoctamin 1 reveals a subtle role for BK channels in lymphatic muscle action potentials.

Rebecca C Harlow, Grace A Pea, Sarah E Broyhill, Advaya Patro, Karen H Bromert, Randolph H Stewart, Cristine L Heaps, Jorge A Castorena-Gonzalez, Ranjeet M Dongaonkar, Scott D Zawieja

Abstract read
In one paragraph

Article in The Journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rebecca C HarlowDepartment of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, USA.ORCID 0000-0002-2933-5731
Grace A PeaDepartment of Medical Pharmacology & Physiology, University of Missouri, Columbia, MO, USA.
Sarah E BroyhillDepartment of Medical Pharmacology & Physiology, University of Missouri, Columbia, MO, USA.ORCID 0000-0003-2627-3368
Advaya PatroDepartment of Medical Pharmacology & Physiology, University of Missouri, Columbia, MO, USA.
Karen H BromertDepartment of Medical Pharmacology & Physiology, University of Missouri, Columbia, MO, USA.
Randolph H StewartDepartment of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, USA.ORCID 0000-0002-3867-1016
Cristine L HeapsDepartment of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, USA.ORCID 0000-0003-4080-8437
Jorge A Castorena-GonzalezDepartment of Pharmacology, Tulane University, New Orleans, LA, USA.ORCID 0000-0001-5252-375X
Ranjeet M DongaonkarDepartment of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, USA.
Scott D ZawiejaDepartment of Medical Pharmacology & Physiology, University of Missouri, Columbia, MO, USA.ORCID 0000-0003-4658-3179

Funding

Trpv4 regulation of lymphatic vascular function: Implications in metabolic syndromeR01HL168568 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI Jorge Augusto Castorena · 2023 to 2026
$1.9M
The Regulation of Lymphatic Muscle Cell Pacemaking by Intracellular Calcium SignalsR00HL143198 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAWIEJA, SCOTT D. · 2021 to 2023
$747k
Endothelial dependent mechanisms of lymphatic dysfunction in metabolic syndrome and type-2 diabetes associated with obesityR00HL141143 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI CASTORENA, JORGE AUGUSTO · 2020 to 2022
$746k
The Regulation of Lymphatic Muscle Cell Pacemaking by Intracellular Calcium SignalsK99HL143198 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAWIEJA, SCOTT D. · 2019 to 2020
$203k
Endothelial dependent mechanisms of lymphatic dysfunction in metabolic syndrome and type-2 diabetes associated with obesityK99HL141143 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CASTORENA, JORGE AUGUSTO · 2019 to 2020
$193k
NHLBI NIH HHS K99 HL141143NHLBI NIH HHS K99 HL143198NHLBI NIH HHS R00 HL141143NHLBI NIH HHS R00 HL143198NHLBI NIH HHS R01 HL168568
6 · The paper itself

Abstract

Ca

Indexed as

Action PotentialsAnoctamin-1Large-Conductance Calcium-Activated Potassium ChannelsLymphatic VesselsAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMuscle ContractionMyocytes, Smooth MuscleRatsRats, Sprague-DawleyANO1 protein, mouseAnoctamin-1Large-Conductance Calcium-Activated Potassium Channelsaction potentialANO1 channelBK channellymphatics

Identifiers

PMID38704841
PMCPMC11250503

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.