SynthesisClinical oral investigations2024
Autogenous graft versus collagen matrices for peri-implant soft tissue augmentation. A systematic review and network meta-analysis.
Synthesis in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Xenogeneic Collagen Matrix Versus Connective Tissue Graft to Enhance Soft Tissue Profile Around Single Dental Implants in the Aesthetic Zone
Effects of Ribose Cross-Linked Thick Collagen Membranes and Connective Tissue Grafts on Peri-Implant Tissue
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Autogenous grafts versus substitute scaffolds for soft tissue augmentation in implant therapy: A systematic review.Journal of periodontology · 2026Pooled it
- Esthetic and patient-reported outcomes in immediate implants with adjunctive surgical procedures to increase soft tissue thickness/height: A systematic review.Periodontology 2000 · 2025Pooled it
- Hard and soft tissue alterations after the application of different soft tissue grafting materials during immediate dental implant placement: a systematic review and Bayesian network meta-analysis.BMC oral health · 2025Pooled it
- Clinical outcomes of free gingival graft, xenogeneic collagen matrix, and acellular dermal matrix for peri-implant keratinized mucosa augmentation: a randomized controlled trial.Clinical oral investigations · 2026Trial
- Platelet-rich fibrin versus acellular dermal matrix for vertical soft tissue augmentation simultaneously with dental implantation: a 3-month randomized pilot clinical trial.BMC oral health · 2025Trial
- Review
- Subepithelial Connective Tissue Grafting Around Dental Implants: From Established Soft-Tissue Benefits to Uncertain Marginal Bone Effects.Journal of clinical medicine · 2026Review
- Comparative outcomes of xenogeneic collagen matrices and autogenous graft-based techniques to increase mucosal thickness and keratinised mucosa width at implant sites: are autologous grafts still the gold standard? A systematic review and meta-analysis of randomised clinical trials.Journal of periodontal & implant science · 2026Review
- Adjunctive effect of soft tissue grafting in the surgical treatment of peri-implantitis: clinical and radiographic outcomes from a preclinical canine experiment.Journal of periodontal & implant science · 2026Article
- Heterologous Fibrin Biopolymer as a Key Scaffold for Bone Regeneration: Synergistic Effects with Photobiomodulation and Membrane Therapy.Gels (Basel, Switzerland) · 2026Article
- The Role and Involvement of Functional Three-Dimensional Porcine-Derived Collagen Matrix Biomaterials in Periodontal Regeneration: A Comprehensive Review.Journal of functional biomaterials · 2025Review
- Analysis of the Expression and Activity of Cyclooxygenases COX-1 and COX-2 in THP-1 Monocytes and Macrophages Cultured with Xenogenic Collagen Matrices Biofunctionalized with the Injectable Platelet-Rich Fibrin.International journal of molecular sciences · 2025Article
- Biomaterials for Guided Tissue Regeneration and Guided Bone Regeneration: A Review.Dentistry journal · 2025Review
- Evaluation of palatal mucosal thickness in maxillary posterior teeth using cone-beam computed tomography combined with intraoral scanning: a cross-sectional study on correlating factors.BMC oral health · 2025Article
- Immediate Implant Placement with Soft Tissue Augmentation Using Acellular Dermal Matrix Versus Connective Tissue Graft: A Systematic Review and Meta-Analysis.Materials (Basel, Switzerland) · 2024Review
- Consensus Report by the Italian Academy of Osseointegration on the Importance of Peri-Implant Soft Tissues.Medicina (Kaunas, Lithuania) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe primary objective of this review is to compare autogenous soft tissue grafts (connective tissue graft - CTG and free gingival graft-FGG) with different type of matrices (acellular dermal matrix-ADM, xenograft collagen matrix-XCM, volume-stable collagen matrix-VCMX) used to increase peri-implant soft tissues. MATERIALS AND
methodsA search on electronic databases was performed to identify randomized and non-randomized controlled trials (RCTs and CCTs, respectively) with either parallel or split-mouth design, and treating ≥ 10 patients. A network meta-analysis (NMA) was used to compare different matrices. Soft tissue thickness dimensional changes and keratinized width (KMW) changes were the primary outcome measures. The secondary outcomes were to evaluate: a) PROMs; b) volumetric changes; c) surgical operating time; and d) different periodontal measurements.
resultsA total of 23 studies were included in the qualitative analysis, and 16 studies (11 RCTs and 5 CCTs) in the quantitative analysis. A total of N = 573 sites were evaluated for NMA. CTG resulted the best material for increasing peri-implant soft tissue thickness, at 180 and 360 days after surgery. The use of an ADM showed good results for buccal thickness increase, primarily in the first three months after surgery. Vestibuloplasty + FGG resulted in the most effective technique for peri-implant KMW augmentation, after 180 days.
conclusionsWhile CTG demonstrated better performance in all the comparison and FGG showed to be the best graft to increase keratinized mucosa up to 90 days, ADM and VCMX may be used to increase soft tissue horizontal thickness with lower patients' morbidity. LIMITATIONS: The limits of this NMA are the following: a) limited number of included studies; b) high heterogeneity among them (number of patients, treatment sites, surgical techniques, outcome measures, and follow-ups). CLINICAL RELEVANCE: Many studies compared the efficacy of autogenous and non-autogenous grafts in terms of gingival thickness, volume, and keratinized width increase. However, there is still not clear overall evidence on this topic. This NMA helps clinicians to choose the right material in different peri-implant soft tissue procedures. Recommendations for future studies are mandatory.
Indexed as
Identifiers
38704784What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.