Evidence map›Paper›PMID 38704731›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Logic-Based Strategy for Spatiotemporal Release of Dual Extracellular Vesicles in Osteoarthritis Treatment.

Shiyu Li, Weihan Zheng, Wenfeng Deng, Ziyue Li, Jiaxin Yang, Huihui Zhang, Zhenning Dai, Weiwei Su, Zi Yan, Wanting Xue and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shiyu LiGuangdong Medical Innovation Platform for Translation of 3D Printing Application, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510630, China.ORCID 0000-0002-2045-0012
Weihan ZhengGuangdong Medical Innovation Platform for Translation of 3D Printing Application, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510630, China.
Wenfeng DengGuangdong Medical Innovation Platform for Translation of 3D Printing Application, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510630, China.
Ziyue LiGuangdong Medical Innovation Platform for Translation of 3D Printing Application, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510630, China.
Jiaxin YangGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Huihui ZhangGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Zhenning DaiDepartment of Stomatology, Guangdong Provincial Key Laboratory of Research and Development in Traditional Chinese Medicine, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou, 510095, China.
Weiwei SuGuangdong Medical Innovation Platform for Translation of 3D Printing Application, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510630, China.
Zi YanGuangdong Medical Innovation Platform for Translation of 3D Printing Application, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510630, China.
Wanting XueGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Xinyi YunGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Siqi MiGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Jianlin ShenDepartment of Orthopedics, Affiliated Hospital of Putian University, Putian, 351100, China.
Xiang LuoGuangdong Medical Innovation Platform for Translation of 3D Printing Application, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510630, China.
Ling WangBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.
Yaobin WuGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Wenhua HuangGuangdong Medical Innovation Platform for Translation of 3D Printing Application, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510630, China.

Funding

Guangdong Basic and Applied Basic Research Foundation 2020B1515120001Guangdong Basic and Applied Basic Research Foundation 2021A1515111074Guangdong Basic and Applied Basic Research Foundation 2021A1515410010Guangdong Basic and Applied Basic Research Foundation 2021B1515120019Guangxi Key Laboratory of Birth Defects Research and Prevention GXWCHZDKF-2022-21National Key R&D Program of China 2022YFB4600600National Natural Science Foundation of China 82073747National Natural Science Foundation of China 82300018President Foundation of The Third Affiliated Hospital of Southern Medical University YP202223President Foundation of The Third Affiliated Hospital of Southern Medical University YQ2021001Project funded by China Postdoctoral Science Foundation 2021M701620Scientific research project of Traditional Chinese Medicine Bureau of Guangdong Province 20232007
6 · The paper itself

Abstract

To effectively treat osteoarthritis (OA), the existing inflammation must be reduced before the cartilage damage can be repaired; this cannot be achieved with a single type of extracellular vesicles (EVs). Here, a hydrogel complex with logic-gates function is proposed that can spatiotemporally controlled release two types of EVs: interleukin 10 (IL-10)

Indexed as

Disease Models, AnimalExtracellular VesiclesOsteoarthritisAnimalsHumansHydrogelsInterleukin-10MacrophagesMiceRatsSOX9 Transcription FactorHydrogelsInterleukin-10SOX9 Transcription Factorcontrolled releaseextracellular vesiclelogic‐basedosteoarthritisstimulus‐response

Identifiers

PMID38704731
PMCPMC11234466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.