ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Impaired Meningeal Lymphatics and Glymphatic Pathway in Patients with White Matter Hyperintensity.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed.
- Near‑Infrared Photobiomodulation in White‑Matter Disease: From Microglial States to Measurable Endpoints.Neuromolecular medicine · 2026Review
- Macular choriocapillaris perfusion area: a potential biomarker of mild cognitive impairment in patients with cerebral small vessel disease.Stroke and vascular neurology · 2026Observational
- Meningeal lymphatic dysfunction in Alzheimer's disease: molecular mechanisms, clinical implications, and future perspectives.Molecular neurodegeneration · 2026Review
- Glymphatic dysfunction is associated with cognitive impairment in white matter hyperintensities: A DTI-based study.IBRO neuroscience reports · 2026Article
- Meningeal lymphatic dysfunction mediates postoperative sleep deprivation-induced cognitive decline via impaired neuroinflammatory clearance.Journal of neuroinflammation · 2026Article
- Free water in white matter links focal hemodynamic compromise to cognitive impairment in asymptomatic extracranial carotid artery stenosis.BMC medical imaging · 2026Article
- Meningeal macrophages regulate fibroblasts to influence meningeal lymphatic function following traumatic brain injury.Theranostics · 2026Article
- Glymphatic system bridges peripheral and central nervous system changes in classic trigeminal neuralgia.Brain communications · 2026Article
- Glymphatic-meningeal lymphatic system imbalance: a peripheral-to-central inflammatory bridge in perioperative neurocognitive disorders.Frontiers in immunology · 2026Review
- A cross-tissue transcriptome-wide association study identifies novel candidate genes associated with brain glymphatic system function.Molecular brain · 2025Article
- Clearance mechanisms of the glymphatic/lymphatic system in the brain: new therapeutic perspectives for cognitive impairment.Cognitive neurodynamics · 2025Review
- CSF transport at the brain-meningeal border: effects on neurological health and disease.The Lancet. Neurology · 2025Review
- The Relationship Between Glymphatic Function, White Matter Hyperintensity and Cognition: A Structural Equation Model MRI Study.CNS neuroscience & therapeutics · 2025Article
- Meningeal lymphatic drainage: novel insights into central nervous system disease.Signal transduction and targeted therapy · 2025Review
- Impact of enlarged perivascular spaces in the basal ganglia on gait in cerebral small vessel disease.Aging clinical and experimental research · 2025Article
- MUSE and PROPELLER DWI for ADC in parasagittal dura: insights from high-resolution and reduced-distortion DWI.Scientific reports · 2025Article
- Article
- Impaired Meningeal Lymphatics and Glymphatic Pathway in Patients with White Matter Hyperintensity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Choroid plexus asymmetry predicts decline in fundus blood flow in white matter hyperintensity patients: insights from SS-OCTA.Therapeutic advances in ophthalmologyArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
White matter hyperintensity (WMH) represents a critical global medical concern linked to cognitive decline and dementia, yet its underlying mechanisms remain poorly understood. Here, humans are directly demonstrated that high WMH burden correlates with delayed drainage of meningeal lymphatic vessels (mLVs) and glymphatic pathway. Additionally, a longitudinal cohort study reveals that glymphatic dysfunction predicts WMH progression. Next, in a rat model of WMH, the presence of impaired lymphangiogenesis and glymphatic drainage is confirmed, followed by elevated microglial activation and white matter demyelination. Notably, enhancing meningeal lymphangiogenesis through adeno-associated virus delivery of vascular endothelial growth factor-C (VEGF-C) mitigates microglial gliosis and white matter demyelination. Conversely, blocking the growth of mLVs with a VEGF-C trap strategy exacerbates these changes. The findings highlight the role of mLVs and glymphatic pathway dysfunction in aggravating brain white matter injury, providing a potential novel strategy for WMH prevention and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.