ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Sex-Specific Association Between Childhood Adversity and Accelerated Biological Aging.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Plasma proteomic signatures of childhood adversity.Protein & cell · 2026Article
- Emerging Perspectives on Adverse Childhood Experiences and Brain Cancer Immunotherapy.Cancers · 2026Article
- Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing.BMC medicine · 2026Article
- Longer leukocyte telomere length increases the odds of premature rupture of membranes: a cross-sectional study based on UK Biobank.Scientific reports · 2026Article
- Early life adversity, educational attainment, and cardiometabolic risk among middle-aged and older adults in the United States.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Effects of intergenerational parent-child separation on early eruption of permanent molar and telomere length: a cross-sectional study among Chinese children aged 3-6 years.BMC oral health · 2026Article
- Article
- The Association Between Accelerated Biological Aging and the Physical, Psychological, and Cognitive Multimorbidity and Life Expectancy: Cohort Study.Aging cell · 2025Article
- Adverse Childhood Experiences, Genetic Susceptibility, and the Risk of Osteoporosis: A Cohort Study.Medicina (Kaunas, Lithuania) · 2025Article
- Vitamin E intake mediates the associations of triglyceride-glucose index and its related parameters with phenotypic age acceleration in middle-aged and elderly population.Scientific reports · 2025Article
- Association of biological aging acceleration transitions and burdens with incident cardiovascular disease: longitudinal insights from a national cohort study.BMC medicine · 2025Article
- Sex-dependent impact of parental verbal abuse on brain lateralization of language.Neurobiology of stress · 2025Article
- Longitudinal associations between early-life adversity and accelerated molar eruption: the dimensional and cumulative approach.BMC oral health · 2025Article
- The relationship between physical activity and depression, anxiety, and stress in college students: a mediating effect of diet.Frontiers in nutrition · 2025Article
- Sex-Specific Association Between Childhood Adversity and Accelerated Biological Aging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The moderating role of parent-child interaction in the relationship between maltreatment and psychological well-being among preschool children.Frontiers in psychology · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Is childhood adversity associated with biological aging, and if so, does sex modify the association, and do lifestyle and mental health mediate the association? A lifespan analysis is conducted using data on 142 872 participants from the UK Biobank to address these questions. Childhood adversity is assessed through the online mental health questionnaire (2016), including physical neglect, physical abuse, emotional neglect, emotional abuse, sexual abuse, and a cumulative score. Biological aging is indicated by telomere length (TL) measured from leukocyte DNA using qPCR, and the shorter TL indicates accelerated biological aging; a lifestyle score is constructed using body mass index, physical activity, drinking, smoking, and diet; mental disorder is assessed using depression, anxiety, and insomnia at the baseline survey. The results reveal a sex-specific association such that childhood adversity is associated with shorter TL in women after adjusting for covariates including polygenic risk score for TL, but not in men. Unhealthy lifestyle and mental disorder partially mediate the association in women. The proportions of indirect effects are largest for sexual and physical abuse. These findings highlight the importance of behavioral and psychological interventions in promoting healthy aging among women who experienced childhood adversity, particularly sexual and physical abuse.
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Registered trials
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