Evidence map›Paper›PMID 38704679›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

A Novel Nanozyme to Enhance Radiotherapy Effects by Lactic Acid Scavenging, ROS Generation, and Hypoxia Mitigation.

Yiran Yao, Ru Xu, Weihuan Shao, Ji Tan, Shaoyun Wang, Shuhan Chen, Ai Zhuang, Xuanyong Liu, Renbing Jia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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  17. Multifunctional CuFrontiers in chemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yiran YaoDepartment of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, P. R. China.ORCID 0000-0002-2573-5332
Ru XuState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
Weihuan ShaoDepartment of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, P. R. China.
Ji TanState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
Shaoyun WangDepartment of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, P. R. China.
Shuhan ChenState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
Ai ZhuangDepartment of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, P. R. China.ORCID 0000-0002-7101-371X
Xuanyong LiuState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
Renbing JiaDepartment of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, P. R. China.

Funding

China Postdoctoral Science Foundation 2023M732306National Natural Science Foundation of China 12275178National Natural Science Foundation of China 12305396National Natural Science Foundation of China 82388101National Natural Science Foundation of China U21A20100School of Medicine, Shanghai Jiao Tong University SHSMU-ZDCX20210900School of Medicine, Shanghai Jiao Tong University SHSMU-ZDCX20210902Science and Technology Commission of Shanghai 19JC1410200Science and Technology Commission of Shanghai 20DZ2270800Science and Technology Commission of Shanghai 23ZR1438400Shanghai Key Clinical Specialty, Shanghai Eye Disease Research Center 2022ZZ01003Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine JYJC202210Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine YG2023QNB15
6 · The paper itself

Abstract

Uveal melanoma (UM) is a leading intraocular malignancy with a high 5-year mortality rate, and radiotherapy is the primary approach for UM treatment. However, the elevated lactic acid, deficiency in ROS, and hypoxic tumor microenvironment have severely reduced the radiotherapy outcomes. Hence, this study devised a novel CoMnFe-layered double oxides (LDO) nanosheet with multienzyme activities for UM radiotherapy enhancement. On one hand, LDO nanozyme can catalyze hydrogen peroxide (H

Indexed as

Lactic AcidMelanomaReactive Oxygen SpeciesTumor MicroenvironmentAnimalsCell Line, TumorDisease Models, AnimalHumansMiceNanostructuresUveal MelanomaUveal NeoplasmsLactic AcidReactive Oxygen Specieslactic acid scavenginglayered double oxidesnanozymeradiotherapy sensitizationuveal melanoma

Identifiers

PMID38704679
PMCPMC11234405

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.