ArticleAnnals of clinical microbiology and antimicrobials2024
Genomic epidemiology reveals multiple mechanisms of linezolid resistance in clinical enterococci in China.
Article in Annals of clinical microbiology and antimicrobials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Designing the Next Generation of Antibiotics: Structure, SAR, and Strategy in Medicinal Chemistry (2000-2025).Medicinal research reviews · 2026Review
- Molecular Detection of Linezolid Resistance Determinants and Identification of a Novel C2626T Mutation in Clinical Isolates ofAntibiotics (Basel, Switzerland) · 2026Article
- Emergence of Linezolid Resistance GenesInternational journal of molecular sciences · 2026Article
- Article
- Linezolid in the Focus of Antimicrobial Resistance ofInternational journal of molecular sciences · 2025Review
- Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China.BMC infectious diseases · 2025Article
- Emergence of Linezolid Resistance GenesAntibiotics (Basel, Switzerland) · 2025Article
- First Detection and Genomic Characterization of Linezolid-ResistantMicroorganisms · 2025Article
- Molecular Characterization of Linezolid-Non-SusceptibleInfection and drug resistance · 2025Article
- Prevalence and genetic diversity ofFrontiers in microbiology · 2024Article
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10 authors.
Funding
Abstract
backgroundInfections caused by linezolid-resistant enterococci (LRE) are clinically difficult to treat and threaten patient health. However, there is a lack of studies on long time-span LRE strains in China. For this reason, our study comprehensively revealed the resistance mechanisms of LRE strains collected in a Chinese tertiary care hospital from 2011 to 2022.
methodsEnterococcal strains were screened and verified after retrospective analysis of microbial data. Subsequently, 65 LRE strains (61 Enterococcus faecalis and 4 Enterococcus faecium, MIC ≥ 8 µg/ml), 1 linezolid-intermediate Enterococcus faecium (MIC = 4 µg/ml) and 1 linezolid-susceptible Enterococcus faecium (MIC = 1.5 µg/ml) were submitted for whole-genome sequencing (WGS) analysis and bioinformatics analysis.
resultsThe optrA gene was found to be the most common linezolid resistance mechanism in our study. We identified the wild-type OptrA and various OptrA variants in 98.5% of LRE strains (61 Enterococcus faecalis and 3 Enterococcus faecium). We also found one linezolid-resistant Enterococcus faecium strain carried both optrA and cfr(D) gene, while one linezolid-resistant Enterococcus faecium only harbored the poxtA gene. Most optrA genes (55/64) were located on plasmids, with impB-fexA-optrA, impB-fexA-optrA-erm(A), fexA-optrA-erm(A), and fexA-optrA segments. A minority of optrA genes (9/64) were found on chromosomes with the Tn6674-like platform. Besides, other possible linezolid resistance-associated mechanisms (mutations in the rplC and rplD genes) were also found in 26 enterococcal strains.
conclusionsOur study suggested that multiple mechanisms of linezolid resistance exist among clinical LRE strains in China.
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