Evidence map›Paper›PMID 38704498›Full record

ArticleMolecular biology reports2024

Heterozygous RB1 mutation enhanced ATP production in human iPSC-derived retinal organoids.

Ambily Vincent, Subramanian Krishnakumar, Sowmya Parameswaran

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Retinal Organoids: Innovative Tools for Understanding Retinal Degeneration.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ambily VincentRadheshyam Kanoi Stem Cell Laboratory, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Vision Research Foundation, 41, College Road, Chennai, Tamilnadu, India.
Subramanian KrishnakumarRadheshyam Kanoi Stem Cell Laboratory, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Vision Research Foundation, 41, College Road, Chennai, Tamilnadu, India.
Sowmya ParameswaranRadheshyam Kanoi Stem Cell Laboratory, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Vision Research Foundation, 41, College Road, Chennai, Tamilnadu, India. drpsowmya@snmail.org.

Funding

Department of Biotechnology BT/PR 13929/MED/31/304/2015Indian Council of Medical Research EMDR/SG/9/2023-0470Indian Council of Medical Research F. No. 2019-4208/SCR-BMS
6 · The paper itself

Abstract

backgroundRecent in vitro studies using RB1 METHODS AND

resultsiPSCs were generated from RB1

conclusionThe study provides novel insights into the metabolic phenotype of heterozygous RB1 mutant suggesting dysregulation of energy metabolism and glycolytic pathways to be first step even before the changes in cellular proliferation or other phenotypic consequences ensue.

Indexed as

Adenosine TriphosphateCell DifferentiationInduced Pluripotent Stem CellsOrganoidsRetinaRetinoblastomaRetinoblastoma Binding ProteinsUbiquitin-Protein LigasesGlycolysisHeterozygoteHumansMutationRetinoblastoma ProteinAdenosine TriphosphateRB1 protein, humanRetinoblastoma Binding ProteinsRetinoblastoma ProteinUbiquitin-Protein LigasesHeterozygousPatient-derivedRB1 mutationRetinal organoidRetinoblastomaRNA sequencing

Identifiers

PMID38704498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.