Evidence map›Paper›PMID 38704496›Full record

ArticleDrug delivery and translational research2024

Glycyrrhizin functionalized CuS Nanoprobes for NIR Light-based therapeutic mitigation of acne vulgaris.

Srivathsan Ganeshan, Nidhi Parihar, Donker Chonzom, Dinesh Mohanakrishnan, Rajdeep Das, Dandadhar Sarma, Devipriya Gogoi, Manash Ranjan Das, Suryanarayana Murty Upadhayula, Deepak Bharadwaj Pemmaraju

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Article in Drug delivery and translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Srivathsan Ganeshan *Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, 781101, Assam, India.
Nidhi Parihar *Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, 781101, Assam, India.
Donker ChonzomDepartment of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, 781101, Assam, India.
Dinesh MohanakrishnanDepartment of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, 781101, Assam, India.
Rajdeep DasDepartment of Zoology, Gauhati University, Guwahati, 781014, Assam, India.
Dandadhar SarmaDepartment of Zoology, Gauhati University, Guwahati, 781014, Assam, India.
Devipriya GogoiMaterials Sciences, and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, 785006, Assam, India.
Manash Ranjan DasMaterials Sciences, and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, 785006, Assam, India.
Suryanarayana Murty UpadhayulaDepartment of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, 781101, Assam, India.
Deepak Bharadwaj PemmarajuDepartment of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, 781101, Assam, India. deepak@niperguwahati.in.ORCID 0000-0002-6588-1481

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acne Vulgaris or Acne is a multifactorial bacterial infection caused by Propionibacterium acne, leading to inflammation and decreased quality of life, especially in adolescence. Currently, antibiotics and retinoids are preferred for treating acne. However, their continuous usage may lead to anti-microbial resistance and other side effects. Therefore, research on developing effective strategies to reduce antimicrobial resistance and improve acne healing is ongoing. The current work reports the synthesis and evaluation of near-infrared light-absorbing copper sulfide (CuS) nanoparticles loaded with a biomolecule, Glycyrrhizin (Ga). The photothermal efficacy studies, and in-vitro and in-vivo experiments indicated that the Ga-CuS NPs generated localized hyperthermia in acne-causing bacteria, leading to their complete growth inhibition. The results indicated that the Ga-Cus NPs possess excellent antibacterial and anti-inflammatory properties in the acne and inflammatory models. This could be from the synergistic effect of CuS NPs mediated mild Photothermal effect and inherent pharmacological properties of Ga. Further detailed studies of the formulations can pave the way for application in cosmetic clinics for the effective and minimally invasive management of Acne-like conditions.

Indexed as

Acne VulgarisAnti-Bacterial AgentsCopperGlycyrrhizic AcidInfrared RaysNanoparticlesPropionibacterium acnesAnimalsAnti-Inflammatory AgentsHumansMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsAnti-Inflammatory AgentsCoppercupric sulfideGlycyrrhizic AcidAcne vulgarisAnti-bacterial therapyBiomolecuesInflammationPhotothermal therapy

Identifiers

PMID38704496

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.