Evidence map›Paper›PMID 38704446›Full record

ArticleJournal of exposure science & environmental epidemiology2024

Monitoring human exposure to four parabens and triclosan: comparing silicone wristbands with spot urine samples as predictors of internal dose.

Jessica L Levasseur, Kate Hoffman, Sharon Zhang, Ellen M Cooper, Heather M Stapleton

Abstract readComparative Study
In one paragraph

Article in Journal of exposure science & environmental epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Young infants' exposure to parabens: lotion use as a potential source of exposure.Journal of exposure science & environmental epidemiology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jessica L LevasseurNicholas School of Environment, Duke University, Durham, NC, USA.
Kate HoffmanNicholas School of Environment, Duke University, Durham, NC, USA.
Sharon ZhangNicholas School of Environment, Duke University, Durham, NC, USA.
Ellen M CooperNicholas School of Environment, Duke University, Durham, NC, USA.
Heather M StapletonNicholas School of Environment, Duke University, Durham, NC, USA. heather.stapleton@duke.edu.ORCID 0000-0002-9995-6517

Funding

Research CoreU2CES030851 · NIEHS · DUKE UNIVERSITY · PI STAPLETON, HEATHER M · 2019 to 2025
$6.0M
NIEHS NIH HHS U2C ES030851
6 · The paper itself

Abstract

backgroundPeople are exposed to a variety of chemicals each day as a result of their personal care product (PCP) use.

objectiveThis study was designed to determine if silicone wristbands provide a quantitative estimate of internal dose for phenols commonly associated with PCPs, with a focus on triclosan and four parabens: methyl-, ethyl-, propyl-, and butylparaben. Uptake of these compounds into wristbands and correlations with internal dose were assessed.

methodsTen adults from central North Carolina wore five silicone wristbands, with one wristband removed each day for 5 days. Each participant provided a 24 h urine sample and a random spot urine sample each day, in which paraben and triclosan metabolites were evaluated.

resultsAll parabens and triclosan were detected frequently in wristbands and, except for butylparaben, in urine samples. Wristband and spot urine concentrations of parabens and triclosan were both compared to a measurement of internal dose (i.e., the total metabolite mass excreted over 5 days as a measurement of internal dose). IMPACT STATEMENT: The two most hydrophobic compounds investigated, butylparaben and triclosan, displayed significant linear uptake in wristbands over 5 days, whereas concentrations of methyl- and ethylparaben displayed a steady state concentration. In general, wristbands and spot urine samples were similarly correlated to internal dose for frequently detected parabens and triclosan.  However, wristbands have additional advantages including higher detection rates and reduced participant burden that may make them more suitable tools for assessing exposure to PCPs.

Indexed as

Environmental ExposureParabensSiliconesTriclosanAdultBiological MonitoringCosmeticsEnvironmental MonitoringFemaleHumansMaleMiddle AgedNorth CarolinaWristYoung AdultbutylparabenCosmeticsethyl-p-hydroxybenzoatemethylparabenParabenspropylparabenSiliconesTriclosanBiomonitoringDermal exposureEnvironmental monitoringParabensPersonal exposure

Identifiers

PMID38704446
PMCPMC11303247

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.