Evidence map›Paper›PMID 38704087›Full record

ReviewJournal of advanced research2025

Metabolic reprogramming and interventions in angiogenesis.

Yun Liu, Zifang Wu, Yikun Li, Yating Chen, Xuan Zhao, Miaomiao Wu, Yaoyao Xia

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of advanced research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

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  18. Recent Advances in Nanozymes Toward Diabetic Foot Ulcers.International journal of nanomedicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yun LiuCollege of Animal Science and Technology, Southwest University, Chongqing 400715, China.
Zifang WuCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Yikun LiCollege of Animal Science and Technology, Southwest University, Chongqing 400715, China; College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China.
Yating ChenCollege of Animal Science and Technology, Southwest University, Chongqing 400715, China.
Xuan ZhaoCollege of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: zhaoxuann@swu.edu.cn.
Miaomiao WuAnimal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China. Electronic address: miaomiaowu0316@hunau.edu.cn.
Yaoyao XiaCollege of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: yaoyaoxia20230750@swu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndothelial cell (EC) metabolism plays a crucial role in the process of angiogenesis. Intrinsic metabolic events such as glycolysis, fatty acid oxidation, and glutamine metabolism, support secure vascular migration and proliferation, energy and biomass production, as well as redox homeostasis maintenance during vessel formation. Nevertheless, perturbation of EC metabolism instigates vascular dysregulation-associated diseases, especially cancer. AIM OF REVIEW: In this review, we aim to discuss the metabolic regulation of angiogenesis by EC metabolites and metabolic enzymes, as well as prospect the possible therapeutic opportunities and strategies targeting EC metabolism. KEY SCIENTIFIC CONCEPTS OF REVIEW: In this work, we discuss various aspects of EC metabolism considering normal and diseased vasculature. Of relevance, we highlight that the implications of EC metabolism-targeted intervention (chiefly by metabolic enzymes or metabolites) could be harnessed in orchestrating a spectrum of pathological angiogenesis-associated diseases.

Indexed as

AngiogenesisEndothelial CellsMetabolic ReprogrammingVascular DiseasesAnimalsBlood VesselsHumansNeovascularization, PathologicAngiogenesisAnti-tumor immunityCellular metabolismEndothelial cellInflammation

Identifiers

PMID38704087
PMCPMC11976431

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.