Evidence map›Paper›PMID 38703937›Full record

ArticleBone2024

Conditional loss of CaMKK2 in Osterix-positive osteoprogenitors enhances osteoblast function in a sex-divergent manner.

Brett T Mattingly, Anuradha Valiya Kambrath, Xinchun Ding, William R Thompson, Uma Sankar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brett T MattinglyDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, 635 Barnhill Drive, MS-5035, Indianapolis, IN 46202, USA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, 635 Barnhill Drive, MS-5035, Indianapolis, IN 46202, USA. Electronic address: btmattin@iu.edu.
Anuradha Valiya KambrathDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, 635 Barnhill Drive, MS-5035, Indianapolis, IN 46202, USA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, 635 Barnhill Drive, MS-5035, Indianapolis, IN 46202, USA. Electronic address: anvaliya@iupui.edu.
Xinchun DingDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, 635 Barnhill Drive, MS-5035, Indianapolis, IN 46202, USA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, 635 Barnhill Drive, MS-5035, Indianapolis, IN 46202, USA. Electronic address: xinding@iupui.edu.
William R ThompsonDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, 635 Barnhill Drive, MS-5035, Indianapolis, IN 46202, USA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, 635 Barnhill Drive, MS-5035, Indianapolis, IN 46202, USA; Department of Physical Therapy, School of Health and Human Sciences, 635 Barnhill Drive, MS-5045, Indianapolis, IN 46202, USA. Electronic address: thompwil@iu.edu.
Uma SankarDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, 635 Barnhill Drive, MS-5035, Indianapolis, IN 46202, USA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, 635 Barnhill Drive, MS-5035, Indianapolis, IN 46202, USA. Electronic address: usankar@iu.edu.

Funding

CaMKK2 Signaling in OsteoarthritisR01AR076477 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI SANKAR, UMA · 2020 to 2024
$3.0M
Osteocyte Mechanotransduction and the Gabapentin-Sensitive Matrix-Channel Tethering ComplexR01AR074473 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI THOMPSON, WILLIAM ROY · 2018 to 2023
$2.8M
CaMKK2 Inhibition as a Dual-Action Bone Anabolic and Anti-Catabolic Therapy in OsteoporosisR01AR068332 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI SANKAR, UMA · 2015 to 2019
$2.1M
NIAMS NIH HHS R01 AR068332NIAMS NIH HHS R01 AR074473NIAMS NIH HHS R01 AR076477
6 · The paper itself

Abstract

Ca

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase KinaseOsteoblastsSp7 Transcription FactorAnimalsFemaleGene DeletionMaleMiceMice, KnockoutOsteoclastsOsteogenesisSex CharacteristicsStem CellsCalcium-Calmodulin-Dependent Protein Kinase KinaseCamkk2 protein, mouseSp7 protein, mouseSp7 Transcription FactorCaMKK2Cortical boneOsteoblastsOsteoprogenitorsOsterixTrabecular bone

Identifiers

PMID38703937
PMCPMC11123601

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.