Evidence map›Paper›PMID 38703899›Full record

ArticleNeurotoxicology2024

Everyday home radon exposure is associated with altered structural brain morphology in youths.

OgheneTejiri V Smith, Samantha H Penhale, Lauren R Ott, Danielle L Rice, Anna T Coutant, Ryan Glesinger, Tony W Wilson, Brittany K Taylor

Abstract read
In one paragraph

Article in Neurotoxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Neurosustainability.Frontiers in human neuroscience · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

OgheneTejiri V SmithInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA.
Samantha H PenhaleClinical and Health Psychology Department, University of Florida, Gainesville, FL, USA.
Lauren R OttInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town NE, USA.
Danielle L RiceInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA.
Anna T CoutantInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA.
Ryan GlesingerInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA.
Tony W WilsonInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA; Department of Pharmacology and Neuroscience, Creighton University, Omaha, NE, USA.
Brittany K TaylorInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA; Department of Pharmacology and Neuroscience, Creighton University, Omaha, NE, USA. Electronic address: Brittany.taylor@boystown.org.

Funding

Stress-Induced Aberrations in the Mitochondrial Redox Environment Impact Developing Neural Circuits Supporting Cognitive ControlP20GM144641 · NIGMS · FATHER FLANAGAN'S BOYS' HOME · PI Giorgia Picci · 2022 to 2026
$15.1M
DEVELOPMENTAL MULTIMODAL IMAGING OF NEUROCOGNITIVE DYNAMICS (DEV-MIND)R01MH121101 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2019 to 2023
$5.8M
Pathways to mental health: the mediating role of altered cytokines on the relationship between chronic home radon exposure and emotional neural circuitry in developing youthsR21ES035146 · NIEHS · FATHER FLANAGAN'S BOYS' HOME · PI TAYLOR, BRITTANY · 2023 to 2024
$448k
NIEHS NIH HHS R21 ES035146NIGMS NIH HHS P20 GM144641NIMH NIH HHS R01 MH121101
6 · The paper itself

Abstract

The refinement of brain morphology extends across childhood, and exposure to environmental toxins during this period may alter typical trends. Radon is a highly common radiologic toxin with a well-established role in cancer among adults. However, effects on developmental populations are understudied in comparison. This study investigated whether home radon exposure is associated with altered brain morphology in youths. Fifty-four participants (6-14 yrs, M=10.52 yrs, 48.15% male, 89% White) completed a T1-weighted MRI and home measures of radon. We observed a significant multivariate effect of home radon concentrations, which was driven by effects on GMV. Specifically, higher home radon was associated with smaller GMV (F=6.800, p=.012, η

Indexed as

BrainEnvironmental ExposureMagnetic Resonance ImagingRadonAdolescentAir Pollution, IndoorChildFemaleHumansMaleRadonDevelopmental trajectoryEnvironmental exposureStructural MRIVolumetrics

Identifiers

PMID38703899
PMCPMC11139553

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.