ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2024
Rumination and Overrecruitment of Cognitive Control Circuits in Depression.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Reflection Rumination Reduces Negative Emotional Processing During Goal-Directed Behavior: An ERP Study.Behavioral sciences (Basel, Switzerland) · 2025Article
- Neural correlates of rumination in remitted depressive episodes: Brain network connectivity and topology analyses.World journal of psychiatry · 2025Article
- A randomized controlled trial of computerized cognitive training to improve working memory in individuals with elevated repetitive negative thinking: Behavioral and neural outcomes.Journal of mood and anxiety disorders · 2025Article
- Negative rumination in depression subtypes with melancholic features and anxious distress.Frontiers in psychology · 2025Article
- Impact of Physical Activity, Sedentary Behavior, and Basal Metabolic Rate on PTSD, Depression, and Emotional Instability.Brain sciences · 2024Article
- Brooding rumination predicts lower cognitive functioning in late-life depression: multivariate multiple regression analyses.Journal of clinical and experimental neuropsychologyArticle
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Authors and funding
4 authors.
Funding
Abstract
backgroundRumination is associated with greater cognitive dysfunction and treatment resistance in major depressive disorder (MDD), but its underlying neural mechanisms are not well understood. Because rumination is characterized by difficulty in controlling negative thoughts, the current study investigated whether rumination was associated with aberrant cognitive control in the absence of negative emotional information.
methodsIndividuals with MDD (n = 176) and healthy control individuals (n = 52) completed the stop signal task with varied stop signal difficulty during functional magnetic resonance imaging. In the task, a longer stop signal asynchrony made stopping difficult (hard stop), whereas a shorter stop signal asynchrony allowed more time for stopping (easy stop).
resultsIn participants with MDD, higher rumination intensity was associated with greater neural activity in response to difficult inhibitory control in the frontoparietal regions. Greater activation for difficult inhibitory control associated with rumination was also positively related to state fear. The imaging results provide compelling evidence for the neural basis of inhibitory control difficulties in individuals with MDD with high rumination.
conclusionsThe association between higher rumination intensity and greater neural activity in regions involved in difficult inhibitory control tasks may provide treatment targets for interventions aimed at improving inhibitory control and reducing rumination in this population.
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