ReviewOsteoarthritis and cartilage2024
Unraveling sex-specific risks of knee osteoarthritis before menopause: Do sex differences start early in life?
Review in Osteoarthritis and cartilage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed.
- Minimalist Footwear and Knee Joint Loading During Walking in Healthy Adults: A Systematic Review of Evidence for Osteoarthritis Prevention.Journal of functional morphology and kinesiology · 2026Review
- A Thematic Narrative Review of Osteoarthritis Risk Factors Across the Female Life Course.International journal of molecular sciences · 2026Review
- Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review).International journal of molecular medicine · 2026Review
- From Joint Loading to Osteoarthritis: A Multiscale Review of Knee Mechanobiology and Digital Modelling.International journal of molecular sciences · 2026Review
- Origin of sexual dimorphism in osteoarthritis risk: the impact of pregnancy and parental care.BMC public health · 2026Article
- Sex-related differences in final knee balance during robotic-assisted unicompartmental knee arthroplasty.Archives of orthopaedic and trauma surgery · 2026Article
- Protein Response to ACL Injury in Humans Show Early Cartilage Remodeling and Differences by Sex.bioRxiv : the preprint server for biology · 2026Article
- Synovial inflammatory macrophage-derived extracellular vesicles exacerbate cartilage lesions with a FMRP-selectively sorted manner in osteoarthritis.Bone research · 2026Article
- Osteoarthritis as a systemic disease.Nature reviews. Rheumatology · 2026Review
- Biomechanical effects of squatting movements in Tai Chi on the knee joint.Frontiers in physiology · 2026Article
- Global prevalence, incidence, and years lived with disability (YLDs) of osteoarthritis: trends from 1990 to 2021 and projections to 2050.Journal of orthopaedic translation · 2026Article
- The Effects of Walking Exercise Using Water Inertial Load on Dynamic Balance Ability and Pain in Women Aged 65 Years and Older with Knee Osteoarthritis: A Randomized Clinical Trial.Journal of functional morphology and kinesiology · 2025Article
- Comparison of knee articular cartilage thickness across sex and age groups in healthy adults.Journal of experimental orthopaedics · 2025Article
- Serum TSP-1 is a useful biomarker in severity assessment and the diagnosis of osteoarthritis.Journal of translational medicine · 2025Article
- Association between vitamin D deficiency, inflammatory markers, and knee osteoarthritis: a retrospective study.Journal of orthopaedic surgery and research · 2025Article
- Age-Dependent Meniscal and Chondral Damage in Eastern European Women Undergoing First-Time Knee Arthroscopy.Healthcare (Basel, Switzerland) · 2025Article
- Creating Perforations in the Sclerotic Region of the Proximal Tibia During Total Knee Arthroplasty to Enhance Prosthesis Stability.Orthopaedic surgery · 2025Article
- The Mechanism by Which Estrogen Level Affects Knee Osteoarthritis Pain in Perimenopause and Non-Pharmacological Measures.International journal of molecular sciences · 2025Review
- Epidemiological trends and characteristics of osteoarthritis in China during 1990-2021.Journal of orthopaedic translation · 2025Article
- Efficacy and Safety of Intra-Articular Therapy with Cross-Linked Hyaluronic Acid in Patients with Knee Osteoarthritis.Pharmaceuticals (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveSufficient evidence within the past two decades have shown that osteoarthritis (OA) has a sex-specific component. However, efforts to reveal the biological causes of this disparity have emerged more gradually. In this narrative review, we discuss anatomical differences within the knee, incidence of injuries in youth sports, and metabolic factors that present early in life (childhood and early adulthood) that can contribute to a higher risk of OA in females.
designWe compiled clinical data from multiple tissues within the knee joint-since OA is a whole joint disorder-aiming to reveal relevant factors behind the sex differences from different perspectives.
resultsThe data gathered in this review indicate that sex differences in articular cartilage, meniscus, and anterior cruciate ligament are detected as early as childhood and are not only explained by sex hormones. Aiming to unveil the biological causes of the uneven sex-specific risks for knee OA, we review the current knowledge of sex differences mostly in young, but also including old populations, from the perspective of (i) human anatomy in both healthy and pathological conditions, (ii) physical activity and response to injury, and (iii) metabolic signatures.
conclusionsWe propose that to close the gap in health disparities, and specifically regarding OA, we should address sex-specific anatomic, biologic, and metabolic factors at early stages in life, as a way to prevent the higher severity and incidence of OA in women later in life.
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