Evidence map›Paper›PMID 38703587›Full record

ArticleNuclear medicine and biology

A third generation PSMA-targeted agent [

Yutian Feng, Rebecca L Meshaw, Sean W Finch, Yongxiang Zheng, Il Minn, Ganesan Vaidyanathan, Martin G Pomper, Michael R Zalutsky

Abstract read
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. First-in-human evaluation of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
  4. Effective treatment of human prostate carcinoma xenografts with Single-Dose PSMA-targeted [European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Theranostic Application of Radiohalogens in Nuclear Medicine.Nuclear medicine and molecular imaging · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. Enhancing the therapeutic index of [Nuclear medicine and biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yutian FengDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Rebecca L MeshawDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Sean W FinchDepartment of Physics and Triangle Universities Nuclear Laboratory, Duke University, Durham, NC 27710, USA.
Yongxiang ZhengDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Il MinnRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Ganesan VaidyanathanDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Martin G PomperRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Michael R ZalutskyDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: zalut001@mc.duke.edu.

Funding

Small Molecule PSMA-Targeted Alpha TherapyR01CA184228 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G, ZALUTSKY, MICHAEL ROD · 2014 to 2023
$3.6M
NCI NIH HHS R01 CA184228
6 · The paper itself

Abstract

introductionTargeted α-particle therapy agents have shown promising responses in patients who have developed resistance to β

methodsThe tin precursors and unlabeled iodo standards for [

resultsThe syntheses of tin precursors and unlabeled iodo standards were accomplished in reasonable yields. A streamlined and scalable radiolabeling method (1 h total synthesis time) was developed for the radiosynthesis of both [

conclusion[

Indexed as

Chemistry Techniques, SyntheticRadiochemistryAnimalsAntigens, SurfaceAstatineCell Line, TumorGlutamate Carboxypeptidase IIHumansMaleMiceTissue DistributionAntigens, SurfaceAstatineAstatine-211FOLH1 protein, humanGlutamate Carboxypeptidase II(211)AstatineProstate cancerProstate-specific membrane antigenRadionuclide therapyTargeted alpha-particle therapy

Identifiers

PMID38703587
PMCPMC11180594

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.