Evidence map›Paper›PMID 38703523›Full record

ArticleBrain and language2024

Evidence for planning and motor subtypes of stuttering based on resting state functional connectivity.

Hannah P Rowe, Jason A Tourville, Alfonso Nieto-Castanon, Emily O Garnett, Ho Ming Chow, Soo-Eun Chang, Frank H Guenther

Abstract read
In one paragraph

Article in Brain and language, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Neural subtypes in developmental stuttering.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hannah P RoweBoston University, Boston, MA, USA. Electronic address: hprowe@bu.edu.
Jason A TourvilleBoston University, Boston, MA, USA. Electronic address: jtour@bu.edu.
Alfonso Nieto-CastanonBoston University, Boston, MA, USA.
Emily O GarnettUniversity of Michigan, Ann Arbor, MI, USA. Electronic address: emilyog@umich.edu.
Ho Ming ChowUniversity of Delaware, Newark, DE, USA. Electronic address: hmc@udel.edu.
Soo-Eun ChangUniversity of Michigan, Ann Arbor, MI, USA; Ewha Womans University, Seoul, South Korea. Electronic address: sooeunc@med.umich.edu.
Frank H GuentherBoston University, Boston, MA, USA. Electronic address: guenther@bu.edu.

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Sequencing and Initiation in Speech ProductionR01DC007683 · NIDCD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI FRANK H GUENTHER · 2006 to 2026
$9.0M
Sexual dimorphism of neural development underlying childhood stutteringR01DC011277 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Soo-Eun Chang · 2010 to 2026
$8.2M
Advanced Research Training in Communication Sciences and DisordersT32DC013017 · NIDCD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Cara E. Stepp · 2016 to 2026
$4.9M
NCATS NIH HHS UL1 TR002240NIDCD NIH HHS R01 DC007683NIDCD NIH HHS R01 DC011277NIDCD NIH HHS T32 DC013017
6 · The paper itself

Abstract

We tested the hypothesis, generated from the Gradient Order Directions Into Velocities of Articulators (GODIVA) model, that adults who stutter (AWS) may comprise subtypes based on differing connectivity within the cortico-basal ganglia planning or motor loop. Resting state functional connectivity from 91 AWS and 79 controls was measured for all GODIVA model connections. Based on a principal components analysis, two connections accounted for most of the connectivity variability in AWS: left thalamus - left posterior inferior frontal sulcus (planning loop component) and left supplementary motor area - left ventral premotor cortex (motor loop component). A k-means clustering algorithm using the two connections revealed three clusters of AWS. Cluster 1 was significantly different from controls in both connections; Cluster 2 was significantly different in only the planning loop; and Cluster 3 was significantly different in only the motor loop. These findings suggest the presence of planning and motor subtypes of stuttering.

Indexed as

StutteringAdultBrainBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysRestYoung AdultResting state functional connectivityStutteringSubtyping

Identifiers

PMID38703523
PMCPMC11147703

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.