ArticleInternational journal of hygiene and environmental health2024
Sex and adrenal hormones in association with insecticide biomarkers among adolescents living in ecuadorian agricultural communities.
Article in International journal of hygiene and environmental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Occurrence of insecticides, fungicides, and herbicides in household drinking and irrigation water in an intensive floriculture region of Ecuador.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Sex and adrenal hormone alteration in Ecuadorian adolescents with home and school proximity to floriculture crop area.Environmental health : a global access science source · 2026Article
- The distribution of neonicotinoids and their metabolites in paired semen and urine samples and associations with male reproductive hormones.Frontiers in endocrinology · 2026Article
- Article
- [Determination of 79 pesticide residues in fruits and vegetables by QuEChERS-ultra performance liquid chromatography-tandem mass spectrometry].Se pu = Chinese journal of chromatography · 2025Article
- Associations Between Urinary Pesticide Metabolites and Serum Inflammatory Biomarkers in Adolescents Living in an Agricultural Region.Exposure and health · 2025Article
- How can simple household procedures reduce exposure to pesticides from fruits and vegetables: current habits and recommendations.Arhiv za higijenu rada i toksikologiju · 2025Article
- Human plasma protein bindings of neonicotinoid insecticides and metabolites.Scientific reports · 2025Article
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12 authors.
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Abstract
backgroundOrganophosphate, pyrethroid, and neonicotinoid insecticides have resulted in adrenal and gonadal hormone disruption in animal and in vitro studies; limited epidemiologic evidence exists in humans. We assessed relationships of urinary insecticide metabolite concentrations with adrenal and gonadal hormones in adolescents living in Ecuadorean agricultural communities.
methodsIn 2016, we examined 522 Ecuadorian adolescents (11-17y, 50.7% female, 22% Indigenous; ESPINA study). We measured urinary insecticide metabolites, blood acetylcholinesterase activity (AChE), and salivary testosterone, dehydroepiandrosterone (DHEA), 17β-estradiol, and cortisol. We used general linear models to assess linear (β = % hormone difference per 50% increase of metabolite concentration) and curvilinear relationships (β
resultsThe organophosphate metabolite malathion dicarboxylic acid (MDA) had positive associations with testosterone (β
conclusionsWe observed evidence of endocrine disruption for specific organophosphate and neonicotinoid metabolite exposures in adolescents. Urinary organophosphate metabolites were associated with testosterone and DHEA concentrations, with stronger associations in boys than girls. Urinary neonicotinoids were positively associated with 17β-estradiol. Longitudinal repeat-measures analyses would be beneficial for causal inference.
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