Evidence map›Paper›PMID 38703343›Full record

ArticleMolecular neurobiology2024

Neuroprotective Role of Selenium Nanoparticles Against Behavioral, Neurobiochemical and Histological Alterations in Rats Subjected to Chronic Restraint Stress.

Sarah A Elfakharany, Samir S Eskaros, Nesrine M El Azhary, Doaa A Abdelmonsif, Teshreen M Zeitoun, Gamal A G Ammar, Youssef A Hatem

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In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah A ElfakharanyDepartment of Medical Physiology, Faculty of Medicine, University of Alexandria, Al-Mouassat Medical Campus, El Hadara, Alexandria, Egypt. s_abdelrahman18@alexmed.edu.eg.ORCID http://orcid.org/0000-0003-0928-2270
Samir S EskarosDepartment of Medical Physiology, Faculty of Medicine, University of Alexandria, Al-Mouassat Medical Campus, El Hadara, Alexandria, Egypt.
Nesrine M El AzharyDepartment of Medical Physiology, Faculty of Medicine, University of Alexandria, Al-Mouassat Medical Campus, El Hadara, Alexandria, Egypt.ORCID http://orcid.org/0000-0002-8200-5918
Doaa A AbdelmonsifDepartment of Medical Biochemistry, Faculty of Medicine, University of Alexandria, Al- Moussat Medical Campus, El Hadara, Alexandria, Egypt.ORCID http://orcid.org/0000-0002-6859-1156
Teshreen M ZeitounDepartment of Histology and Cell Biology, Faculty of Medicine, University of Alexandria, Al-Moussat Medical Campus, El Hadara, Alexandria, Egypt.ORCID http://orcid.org/0000-0003-1744-7530
Gamal A G AmmarBiotechnology Unit, Plant Production Department (PPD), Arid Lands Cultivation Research Institute (ALCRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El‑Arab City, Alexandria, Egypt.ORCID http://orcid.org/0000-0003-1836-426X
Youssef A HatemDepartment of Medical Physiology, Faculty of Medicine, University of Alexandria, Al-Mouassat Medical Campus, El Hadara, Alexandria, Egypt.ORCID http://orcid.org/0000-0002-7485-5701

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic stress induces changes in the prefrontal cortex and hippocampus. Selenium nanoparticles (SeNPs) showed promising results in several neurological animal models. The implementation of SeNPs in chronic restraint stress (CRS) remains to be elucidated. This study was done to determine the possible protective effects of selenium nanoparticles on behavioral changes and brain oxidative stress markers in a rat model of CRS. 50 rats were divided into three groups; control group (n = 10), untreated CRS group (n = 10) and CRS-SeNPs treated group (n = 30). Restraint stress was performed 6 h./day for 21 days. Rats of CRS-SeNPs treated group received 1, 2.5 or 5 mg/kg SeNPs (10 rats each) by oral gavage for 21 days. Rats were subjected to behavioral assessments and then sacrificed for biochemical and histological analysis of the prefrontal cortex and hippocampus. Prefrontal cortical and hippocampal serotonin levels, oxidative stress markers including malondialdehyde (MDA), reduced glutathione (GSH) and glutathione peroxidase (GPx), tumor necrosis factor alpha (TNF-α) and caspase-3 were assessed. Accordingly, different doses of SeNPs showed variable effectiveness in ameliorating disease parameters, with 2.5 mg/kg dose of SeNPs showing the best improving results in all studied parameters. The present study exhibited the neuroprotective role of SeNPs in rats subjected to CRS and proposed their antioxidant, anti-inflammatory and anti-apoptotic effects as the possible mechanism for increased prefrontal cortical and hippocampal serotonin level, ameliorated anxiety-like and depressive-like behaviors and improved prefrontal cortical and hippocampal histological architecture.

Indexed as

Behavior, AnimalHippocampusNanoparticlesNeuroprotective AgentsOxidative StressPrefrontal CortexRats, WistarRestraint, PhysicalSeleniumStress, PsychologicalAnimalsMaleRatsSerotoninNeuroprotective AgentsSeleniumSerotoninCaspase-3Chronic restraint stressOxidative stressSelenium nanoparticlesSerotoninTNF-α

Identifiers

PMID38703343
PMCPMC11584447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.