Evidence map›Paper›PMID 38703297›Full record

ReviewEJNMMI radiopharmacy and chemistry2024

Radiation nanomedicines for cancer treatment: a scientific journey and view of the landscape.

Raymond M Reilly, Constantine J Georgiou, Madeline K Brown, Zhongli Cai

Abstract readReview
In one paragraph

Review in EJNMMI radiopharmacy and chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Linking In Vivo Imaging to Therapeutic Outcome withInternational journal of molecular sciences · 2026
    Review
  2. Review
  3. Ultrasmall AuExploration (Beijing, China) · 2026
    Article
  4. Review
  5. Preclinical evaluation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  6. Review
  7. Auger electron-emitting EGFR-targeted and non-targeted [EJNMMI radiopharmacy and chemistry · 2025
    Article
  8. Review
  9. Article
  10. Small science · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Palladium-103 (Theranostics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Raymond M ReillyDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada. raymond.reilly@utoronto.ca.ORCID http://orcid.org/0000-0003-1038-7993
Constantine J GeorgiouDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada.
Madeline K BrownDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada.
Zhongli CaiDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada.

Funding

Brain Tumour Foundation of Canada Research GrantCanadian Cancer Society Innovation GrantCanadian Cancer Society Innovation to Impact AwardNatural Sciences and Engineering Research Council of Canada Discovery GrantNatural Sciences and Engineering Research Council of Canada Polymer Nanoparticles in Drg Delivery (POND) CREATE ProgramTerry Fox Foundation STARS21 ScholarshipUniversity of Toronto MDS Nordion Scholarship in Radiopharmaceutical SciencesWorld Gold Council Funds Donated to the Canadian Cancer Society
6 · The paper itself

Abstract

backgroundRadiation nanomedicines are nanoparticles labeled with radionuclides that emit α- or β-particles or Auger electrons for cancer treatment. We describe here our 15 years scientific journey studying locally-administered radiation nanomedicines for cancer treatment. We further present a view of the radiation nanomedicine landscape by reviewing research reported by other groups. MAIN BODY: Gold nanoparticles were studied initially for radiosensitization of breast cancer to X-radiation therapy. These nanoparticles were labeled with

conclusionsRadiation nanomedicines have shown great promise for treating cancer in preclinical studies. Local intratumoural administration avoids sequestration by the liver and spleen and is most effective for treating tumours, while minimizing normal tissue toxicity.

Indexed as

Block copolymer micellesCancer treatmentConvection-enhanced deliveryDendrimersGold nanoparticlesIntratumoural injectionLiposomesNanomedicinesRadionuclidesRadiosensitization

Identifiers

PMID38703297
PMCPMC11069497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.