Evidence map›Paper›PMID 38703222›Full record

ArticleInternational urogynecology journal2024

Midurethral Sling Mesh Exposure Confers a High Risk of Persistent Stress Urinary Incontinence.

Tamara Siblini, Michael Baracy, Sanjana Kulkarni, Colton Mabis, Karen Hagglund, Muhammad Aslam

Registry-linked trialAbstract read
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In one paragraph

Article in International urogynecology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07414849 (The Amper Study), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07414849 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Amper Study: Amniotic Membrane for the Prevention of Mesh Exposure in Vaginal Reconstructive Surgery

TypeinterventionalSponsorHospital General de Agudos J. M. PennaRan2026 to 2028Enrolled330ConditionsPelvic Organ Prolapse Vaginal Surgery, Stress Urinary Incontinence in WomenArmsSacrospinous Hysteropexy with Mesh, Retropubic Mid-urethral Sling (Bottom-Up), Transobturator Mid-urethral Sling (Out-In)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tamara SibliniDepartment of Obstetrics and Gynecology, Ascension St. John Hospital, 22151 Moross Rd., PB1 Suite 311, Detroit, MI, 48236, USA. Tamara.siblini@ascension.org.ORCID 0009-0009-9902-3221
Michael BaracyDepartment of Obstetrics and Gynecology, Ascension St. John Hospital, 22151 Moross Rd., PB1 Suite 311, Detroit, MI, 48236, USA.
Sanjana KulkarniDepartment of Obstetrics and Gynecology, Ascension St. John Hospital, 22151 Moross Rd., PB1 Suite 311, Detroit, MI, 48236, USA.
Colton MabisDepartment of Obstetrics and Gynecology, Ascension St. John Hospital, 22151 Moross Rd., PB1 Suite 311, Detroit, MI, 48236, USA.
Karen HagglundDepartment of Biomedical Investigations and Research, Ascension St. John Hospital, 22151 Moross Rd., PB1 Suite 311, Detroit, MI, 48236, USA.
Muhammad AslamDepartment of Female Pelvic Medicine and Reconstructive Surgery, Ascension St. John Hospital, 22151 Moross Rd., PB1Suite 311, Detroit, MI, 48236, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and hypothesisThe objective was to investigate the relationship between mesh exposure and persistent stress urinary incontinence (SUI) post-midurethral sling (MUS) surgery.

methodsExtensive data collection including patient demographics, obstetric history, existing medical conditions, previous surgeries, and surgical outcomes, encompassing both perioperative and postoperative complications.

resultsOut of 456 patients who underwent the MUS procedure within the specified period, the persistence of SUI was noted in 6.4% of cases. Mesh exposure was observed in 8.8% of these cases. Notably, 25% of patients with mesh exposure suffered from persistent SUI, in stark contrast to 4.6% of those without mesh exposure (p < 0.0001). Further, multivariate analysis indicated that patients with mesh exposure had an approximately 6.5-fold increased likelihood (95% CI: 2.71-15.44) of experiencing persistent SUI compared with those without mesh exposure.

conclusionsMesh exposure is a significant independent risk factor for persistent SUI post-MUS surgery. Patients with mesh exposure are about 6.5 times more prone to persistent SUI than those without. Although mesh exposure is typically managed with expectant measures, vaginal estrogen or mesh excision, current evidence does not support surgical revision of MUS affected by mesh exposure or additional incontinence procedures during mesh excision.

Indexed as

Suburethral SlingsSurgical MeshUrinary Incontinence, StressAdultAgedFemaleHumansMiddle AgedPostoperative ComplicationsRetrospective StudiesRisk FactorsMesh exposureMidurethral slingMidurethral sling failurePelvic organ prolapsePersistent urinary incontinenceStress urinary incontinence

Identifiers

PMID38703222

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.