Evidence map›Paper›PMID 38703194›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2024

The curvature quantification of wave I in auditory brainstem responses detects cochlear synaptopathy in human beings.

Florian Herrmann Schmidt, Alexander Dörmann, Karsten Ehrt, Wilma Grossmann, Robert Mlynski, Lichun Zhang

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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2 citing papers in PubMed.

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5 · Who and what money

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6 authors.

Florian Herrmann SchmidtDepartment of Otorhinolaryngology, Head and Neck Surgery, Otto Körner, Rostock University Medical Center, Doberaner Strasse 137-139, 18057, Rostock, Germany.
Alexander DörmannDepartment of Otorhinolaryngology, Head and Neck Surgery, Otto Körner, Rostock University Medical Center, Doberaner Strasse 137-139, 18057, Rostock, Germany.
Karsten EhrtDepartment of Otorhinolaryngology, Head and Neck Surgery, Otto Körner, Rostock University Medical Center, Doberaner Strasse 137-139, 18057, Rostock, Germany.
Wilma GrossmannDepartment of Otorhinolaryngology, Head and Neck Surgery, Otto Körner, Rostock University Medical Center, Doberaner Strasse 137-139, 18057, Rostock, Germany.
Robert MlynskiDepartment of Otorhinolaryngology, Head and Neck Surgery, Otto Körner, Rostock University Medical Center, Doberaner Strasse 137-139, 18057, Rostock, Germany.
Lichun ZhangDepartment of Otorhinolaryngology, Head and Neck Surgery, Otto Körner, Rostock University Medical Center, Doberaner Strasse 137-139, 18057, Rostock, Germany. lichun.zhang@med.uni-rostock.de.ORCID http://orcid.org/0000-0002-3964-997X

Funding

Universität Rostock 889028
6 · The paper itself

Abstract

purposePatients with age-related hearing loss complain often about reduced speech perception in adverse listening environment. Studies on animals have suggested that cochlear synaptopathy may be one of the primary mechanisms responsible for this phenomenon. A decreased wave I amplitude in supra-threshold auditory brainstem response (ABR) can diagnose this pathology non-invasively. However, the interpretation of the wave I amplitude in humans remains controversial. Recent studies in mice have established a robust and reliable mathematic algorithm, i.e., curve curvature quantification, for detecting cochlear synaptopathy. This study aimed to determine whether the curve curvature has sufficient test-retest reliability to detect cochlear synaptopathy in aging humans.

methodsHealthy participants were recruited into this prospective study. All subjects underwent an audiogram examination with standard and extended high frequencies ranging from 0.125 to 16 kHz and an ABR with a stimulus of 80 dB nHL click. The peak amplitude, peak latency, curvature at the peak, and the area under the curve of wave I were calculated and analyzed.

resultsA total of 80 individuals with normal hearing, aged 18 to 61 years, participated in this study, with a mean age of 26.4 years. Pearson correlation analysis showed a significant negative correlation between curvature and age, as well as between curvature and extended high frequency (EHF) threshold (10-16 kHz). Additionally, the same correlation was observed between age and area as well as age and EHF threshold. The model comparison demonstrated that the curvature at the peak of wave I is the best metric to correlate with EHF threshold.

conclusionThe curvature at the peak of wave I is the most sensitive metric for detecting cochlear synaptopathy in humans  and may be applied in routine diagnostics to detect early degenerations of the auditory nerve.

Indexed as

CochleaEvoked Potentials, Auditory, Brain StemAdultAgedAlgorithmsAuditory ThresholdFemaleHearing Loss, HiddenHumansMaleMiddle AgedProspective StudiesReproducibility of ResultsSynapsesYoung AdultABRAge-related hearing lossCochlear synaptopathyCurve curvatureExtended high frequency thresholdHidden hearing loss

Identifiers

PMID38703194

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