Evidence map›Paper›PMID 38703041›Full record

ReviewMolecular microbiology2024

The immune interactions of gut glycans and microbiota in health and disease.

Mahmut Demirturk, Mukaddes Sena Cinar, Fikri Y Avci

Abstract readReview
In one paragraph

Review in Molecular microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
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  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mahmut DemirturkDepartment of Biochemistry, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0009-0005-2287-8839
Mukaddes Sena CinarDepartment of Biochemistry, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0009-0006-5949-019X
Fikri Y AvciDepartment of Biochemistry, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-1902-7532

Funding

Molecular Mechanisms for Carbohydrate Presentation to CD4+ T cells by MHCII PathwayR01AI123383 · NIAID · UNIVERSITY OF GEORGIA · PI Fikri Y Avci · 2016 to 2026
$4.2M
Glycopeptide-specific helper T cells eliciting protective humoral immunity against HIV - ResubmissionR01AI152766 · NIAID · UNIVERSITY OF GEORGIA · PI Fikri Y Avci · 2021 to 2026
$2.6M
Pn3Pase as an Effective Enzyme Therapeutic for Streptococcus Pneumoniae type 3 InfectionR41AI157287 · NIAID · PNEUMOTACTIX, LLC · PI AVCI, FIKRI Y · 2021 to 2022
$599k
National Institute of Allergy and Infectious Diseases R01AI123383National Institute of Allergy and Infectious Diseases R01AI152766National Institute of Allergy and Infectious Diseases R41AI157287NIAID NIH HHS R01 AI123383NIAID NIH HHS R01 AI152766NIAID NIH HHS R41 AI157287
6 · The paper itself

Abstract

The human digestive system harbors a vast diversity of commensal bacteria and maintains a symbiotic relationship with them. However, imbalances in the gut microbiota accompany various diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancers (CRCs), which significantly impact the well-being of populations globally. Glycosylation of the mucus layer is a crucial factor that plays a critical role in maintaining the homeostatic environment in the gut. This review delves into how the gut microbiota, immune cells, and gut mucus layer work together to establish a balanced gut environment. Specifically, the role of glycosylation in regulating immune cell responses and mucus metabolism in this process is examined.

Indexed as

Gastrointestinal MicrobiomeInflammatory Bowel DiseasesPolysaccharidesAnimalsBacteriaColorectal NeoplasmsGlycosylationHomeostasisHumansIntestinal MucosaMucusPolysaccharidesgut immunitygut microbiotagut mucosainflammatory bowel diseasesMUC2mucin glycosylation

Identifiers

PMID38703041
PMCPMC13036616

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.