Evidence map›Paper›PMID 38702976›Full record

ArticleHead & neck2024

How far are we off? Analyzing the accuracy of surgical margin relocation in the head and neck.

Alexis Miller, Vickie Wang, Victor Jegede, Fabian Necker, Joseph Curry, Fred M Baik, Avanti Verma, F Christopher Holsinger, Madalina Tuluc, Mobeen Rahman and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Augmented Reality-based Guidance with Deformable Registration in Head and Neck Tumor Resection.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexis MillerDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-0406-7168
Vickie WangDivision of Otolaryngology, Department of Surgery, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0009-0005-5332-7810
Victor JegedeLewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Fabian NeckerInstitute of Functional and Clinical Anatomy, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Joseph CurryDepartment of Otolaryngology - Head & Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Fred M BaikDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
Avanti VermaDivision of Otolaryngology, Department of Surgery, Yale School of Medicine, New Haven, Connecticut, USA.
F Christopher HolsingerDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
Madalina TulucDepartment of Pathology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Mobeen RahmanDepartment of Pathology, Stanford University, Palo Alto, California, USA.
James S LewisDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Eben RosenthalDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-0294-5203
Michael C TopfDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-1022-4417

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
NCI NIH HHS K12 CA090625This work was supported by a Vanderbilt Clinical Oncology Research Career Development Program K12NCI2K12CA090625-22A1Vanderbilt Clinical Oncology Research Career Development Program K12NCI2K12CA090625-22A1
6 · The paper itself

Abstract

backgroundPositive surgical margin rates remain high in head and neck cancer surgery. Relocation is challenging given the complex, three-dimensional (3D) anatomy.

methodsProspective, multi-institutional study to determine accuracy of head and neck surgeons and pathologists relocating margins on virtual 3D specimen models using written descriptions from pathology reports. Using 3D models of 10 head and neck surgical specimens, each participant relocated 20 mucosal margins (10 perpendicular, 10 shave).

resultsA total of 32 participants, 23 surgeons and 9 pathologists, marked 640 margins. Of the 320 marked perpendicular margins, 49.7% were greater than 1 centimeter from the true margin with a mean relocation error of 10.2 mm. Marked shave margins overlapped with the true margin a mean 54% of the time, with no overlap in 44 of 320 (13.8%) shave margins.

conclusionsSurgical margin relocation is imprecise and challenging even for experienced surgeons and pathologists. New communication technologies are needed.

Indexed as

Head and Neck NeoplasmsMargins of ExcisionFemaleHumansImaging, Three-DimensionalMaleProspective Studieshead and neck cancermargin relocationre‐resectionsurgical margins

Identifiers

PMID38702976
PMCPMC12032842

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.