Evidence map›Paper›PMID 38702966›Full record

ReviewNeuro-oncology2024

Radioligand therapies in meningioma: Evidence and future directions.

Maximilian J Mair, Emeline Tabouret, Derek R Johnson, Erik P Sulman, Patrick Y Wen, Matthias Preusser, Nathalie L Albert

Abstract readReview
In one paragraph

Review in Neuro-oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Tumour-absorbed dose and efficacy of peptide receptor radionuclide therapy with [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Article
  3. Review
  4. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  5. Rational Radionuclide Therapy for Recurrent Meningioma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  6. Validation of SUV thresholds in [¹⁸F]SiTATE PET/CT for accurate meningioma segmentation.European journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maximilian J MairDepartment of Nuclear Medicine, LMU Hospital, LMU Munich, Munich, Germany.ORCID 0000-0002-6537-3874
Emeline TabouretAix-Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, GlioME Team, plateforme PETRA, CHU Timone, Service de Neurooncologie, Marseille, France.
Derek R JohnsonDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Erik P SulmanBrain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone, New York, New York, USA.
Patrick Y WenCenter for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID 0000-0002-0774-7700
Matthias PreusserDivision of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-3541-2315
Nathalie L AlbertDepartment of Nuclear Medicine, LMU Hospital, LMU Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meningiomas are the most common intracranial neoplasms in adults. While most meningiomas are cured by resection, further treatment by radiotherapy may be needed, particularly in WHO grades 2 and 3 tumors which have an increased risk of recurrence, even after conventional therapies. Still, there is an urgent need for novel therapeutic strategies after the exhaustion of local treatment approaches. Radionuclide therapies combine the specificity of tumor-specific antibodies or ligands with the cytotoxic activity of radioactive emitters. Alongside this, integrated molecular imaging allows for a noninvasive assessment of predictive biomarkers as treatment targets. Whereas the concept of "theranostics" has initially evolved in extracranial tumors such as thyroid diseases, neuroendocrine tumors, and prostate cancer, data from retrospective case series and early phase trials underscore the potential of this strategy in meningioma. This review aims to explore the available evidence of radionuclide treatments and ongoing clinical trial initiatives in meningioma. Moreover, we discuss optimal clinical trial design and future perspectives in the field, including compound- and host-specific determinants of the efficacy of "theranostic" treatment approaches.

Indexed as

Meningeal NeoplasmsMeningiomaRadiopharmaceuticalsHumansLigandsLigandsRadiopharmaceuticalsmeningiomanuclear medicinepositron emission tomographyradionuclide treatmenttheranostic

Identifiers

PMID38702966
PMCPMC11631075

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.