Evidence map›Paper›PMID 38702738›Full record

ArticleMolecular brain2024

Chronic pain enhances excitability of corticotropin-releasing factor-expressing neurons in the oval part of the bed nucleus of the stria terminalis.

Ryoko Uchida, Yasutaka Mukai, Taiju Amano, Kenji Sakimura, Keiichi Itoi, Akihiro Yamanaka, Masabumi Minami

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ryoko UchidaDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Yasutaka MukaiDepartment of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464-8601, Aichi, Japan.
Taiju AmanoDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Kenji SakimuraDepartment of Animal Model Development, Brain Research Institute, Niigata University, Niigata, 951-8585, Japan.
Keiichi ItoiDepartment of Nursing, Tohoku Fukushi University, Sendai, 981-8522, Japan.
Akihiro YamanakaDepartment of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464-8601, Aichi, Japan.
Masabumi MinamiDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan. mminami@pharm.hokudai.ac.jp.ORCID 0000-0002-0144-0679

Funding

Japan Agency for Medical Research and Development 23gm1510008h0002Japan Society for the Promotion of Science 20H03389Japan Society for the Promotion of Science 23H02638
6 · The paper itself

Abstract

We previously reported that enhanced corticotropin-releasing factor (CRF) signaling in the bed nucleus of the stria terminalis (BNST) caused the aversive responses during acute pain and suppressed the brain reward system during chronic pain. However, it remains to be examined whether chronic pain alters the excitability of CRF neurons in the BNST. In this study we investigated the chronic pain-induced changes in excitability of CRF-expressing neurons in the oval part of the BNST (ovBNST

Indexed as

Chronic PainCorticotropin-Releasing HormoneNeuronsSeptal NucleiAction PotentialsAnimalsMaleMiceMice, Inbred C57BLCorticotropin-Releasing HormoneBed nucleus of the stria terminalisChronic painCorticotropin-releasing factorNegative emotionNeuronal excitability

Identifiers

PMID38702738
PMCPMC11071157

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.