Evidence map›Paper›PMID 38702518›Full record

ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2024

The role of focused ultrasound for pediatric brain tumors: current insights and future implications on treatment strategies.

Kelsi M Chesney, Gregory F Keating, Nirali Patel, Lindsay Kilburn, Adriana Fonseca, Cheng-Chia Wu, Javad Nazarian, Roger J Packer, Daniel A Donoho, Chima Oluigbo and 3 more

Abstract readReview
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In one paragraph

Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kelsi M ChesneyDepartment of Neurosurgery, Children's National Hospital, Washington, DC, USA.
Gregory F KeatingDepartment of Neurosurgery, Children's National Hospital, Washington, DC, USA.
Nirali PatelDepartment of Neurosurgery, Children's National Hospital, Washington, DC, USA.
Lindsay KilburnBrain Tumor Institute, Children's National Hospital, Washington, DC, USA.
Adriana FonsecaBrain Tumor Institute, Children's National Hospital, Washington, DC, USA.
Cheng-Chia WuDepartment of Radiation Oncology, Columbia University Irving Medical Center, New York, NY, USA.
Javad NazarianBrain Tumor Institute, Children's National Hospital, Washington, DC, USA.
Roger J PackerBrain Tumor Institute, Children's National Hospital, Washington, DC, USA.
Daniel A DonohoDepartment of Neurosurgery, Children's National Hospital, Washington, DC, USA.
Chima OluigboDepartment of Neurosurgery, Children's National Hospital, Washington, DC, USA.
John S MyserosDepartment of Neurosurgery, Children's National Hospital, Washington, DC, USA.
Robert F KeatingDepartment of Neurosurgery, Children's National Hospital, Washington, DC, USA.
Hasan R SyedDepartment of Neurosurgery, Children's National Hospital, Washington, DC, USA. syedhr@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFocused ultrasound (FUS) is an innovative and emerging technology for the treatment of adult and pediatric brain tumors and illustrates the intersection of various specialized fields, including neurosurgery, neuro-oncology, radiation oncology, and biomedical engineering.

objectiveThe authors provide a comprehensive overview of the application and implications of FUS in treating pediatric brain tumors, with a special focus on pediatric low-grade gliomas (pLGGs) and the evolving landscape of this technology and its clinical utility.

methodsThe fundamental principles of FUS include its ability to induce thermal ablation or enhance drug delivery through transient blood-brain barrier (BBB) disruption, emphasizing the adaptability of high-intensity focused ultrasound (HIFU) and low-intensity focused ultrasound (LIFU) applications.

resultsSeveral ongoing clinical trials explore the potential of FUS in offering alternative therapeutic strategies for pathologies where conventional treatments fall short, specifically centrally-located benign CNS tumors and diffuse intrinsic pontine glioma (DIPG). A case illustration involving the use of HIFU for pilocytic astrocytoma is presented.

conclusionDiscussions regarding future applications of FUS for the treatment of gliomas include improved drug delivery, immunomodulation, radiosensitization, and other technological advancements.

Indexed as

Brain NeoplasmsChildGliomaHumansUltrasonic TherapyBlood-brain barrier disruptionClinical trialsFocused ultrasoundGliomaSonodynamic therapy

Identifiers

PMID38702518

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.