Evidence map›Paper›PMID 38702419›Full record

ArticleCommunications biology2024

Persistent T cell unresponsiveness associated with chronic visceral leishmaniasis in HIV-coinfected patients.

Nicky de Vrij, Julia Pollmann, Antonio M Rezende, Ana V Ibarra-Meneses, Thao-Thy Pham, Wasihun Hailemichael, Mekibib Kassa, Tadfe Bogale, Roma Melkamu, Arega Yeshanew and 17 more

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Leishmaniasis.Nature reviews. Disease primers · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Nicky de VrijClinical Immunology Unit, Department of Clinical Sciences, Institute of Tropical Medicine, 2000, Antwerp, Belgium.ORCID 0000-0002-7962-745X
Julia PollmannDepartment of Medical Oncology, University Hospital Heidelberg, National Center for Tumor Diseases (NCT) Heidelberg, 69120, Heidelberg, Germany.ORCID 0000-0001-7240-5910
Antonio M RezendeDepartment of Microbiology, Aggeu Magalhães Institute-FIOCRUZ/PE, Recife, Brazil.ORCID 0000-0003-4775-1779
Ana V Ibarra-MenesesDépartement de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada.
Thao-Thy PhamClinical Immunology Unit, Department of Clinical Sciences, Institute of Tropical Medicine, 2000, Antwerp, Belgium.
Wasihun HailemichaelDepartment of Immunology and Molecular Biology, Faculty of Biomedical Sciences, University of Gondar, Gondar, Ethiopia.ORCID 0000-0003-2721-7632
Mekibib KassaLeishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia.
Tadfe BogaleLeishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia.
Roma MelkamuLeishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia.
Arega YeshanewLeishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia.
Rezika MohammedLeishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia.
Ermias DiroLeishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia.ORCID 0000-0002-3595-6323
Ilse MaesMolecular Parasitology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, 2000, Antwerp, Belgium.
Malgorzata A DomagalskaMolecular Parasitology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, 2000, Antwerp, Belgium.ORCID 0000-0003-0839-0325
Hanne LanduytClinical Trial Unit, Department of Clinical Sciences, Institute of Tropical Medicine, 2000, Antwerp, Belgium.
Florian VogtNational Centre for Epidemiology and Population Health, The Australian National University, Canberra, 2601, Australia.
Saskia van HentenUnit of Neglected Tropical Diseases, Department of Clinical Sciences, Institute of Tropical Medicine, 2000, Antwerp, Belgium.ORCID 0000-0001-6627-0474
Kris LaukensAdrem Data Lab, Department of Computer Science, University of Antwerp, 2020, Antwerp, Belgium.ORCID 0000-0002-8217-2564
Bart CuypersAdrem Data Lab, Department of Computer Science, University of Antwerp, 2020, Antwerp, Belgium.ORCID 0000-0002-7198-1470
Pieter MeysmanAdrem Data Lab, Department of Computer Science, University of Antwerp, 2020, Antwerp, Belgium.ORCID 0000-0001-5903-633X
Hailemariam BeyeneMédecins Sans Frontières, Abdurafi, Ethiopia.
Kasaye SisayMédecins Sans Frontières, Abdurafi, Ethiopia.
Aderajew KibretMédecins Sans Frontières, Abdurafi, Ethiopia.
Dagnew MershaMédecins Sans Frontières, Abdurafi, Ethiopia.
Koert RitmeijerMédecins Sans Frontières, Amsterdam, The Netherlands.
Johan van GriensvenUnit of Neglected Tropical Diseases, Department of Clinical Sciences, Institute of Tropical Medicine, 2000, Antwerp, Belgium.
Wim AdriaensenClinical Immunology Unit, Department of Clinical Sciences, Institute of Tropical Medicine, 2000, Antwerp, Belgium. wadriaensen@itg.be.ORCID 0000-0002-9698-7449

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A large proportion of HIV-coinfected visceral leishmaniasis (VL-HIV) patients exhibit chronic disease with frequent VL recurrence. However, knowledge on immunological determinants underlying the disease course is scarce. We longitudinally profiled the circulatory cellular immunity of an Ethiopian HIV cohort that included VL developers. We show that chronic VL-HIV patients exhibit high and persistent levels of TIGIT and PD-1 on CD8

Indexed as

CoinfectionHIV InfectionsLeishmaniasis, VisceralAdultCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChronic DiseaseEthiopiaFemaleHumansMaleMiddle Aged

Identifiers

PMID38702419
PMCPMC11068874

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.