Evidence map›Paper›PMID 38702345›Full record

ArticleNPJ science of learning2024

Phonological awareness mediates the relationship between DCDC2 and reading performance with home environment.

Miao Li, Mellissa M C DeMille, Maureen W Lovett, Joan Bosson-Heenan, Jan C Frijters, Jeffrey R Gruen, GRaD Study Consortium

Abstract read
In one paragraph

Article in NPJ science of learning, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Miao LiDepartment of Curriculum and Instruction, College of Education, University of Houston, Houston, TX, USA. mli33@central.uh.edu.ORCID http://orcid.org/0000-0002-6756-8122
Mellissa M C DeMilleDepartments of Pediatrics and Genetics, Yale University School of Medicine, New Haven, CT, USA.
Maureen W LovettNeurosciences and Mental Health Program, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Joan Bosson-HeenanDepartments of Pediatrics and Genetics, Yale University School of Medicine, New Haven, CT, USA.
Jan C FrijtersDepartment of Child and Youth Studies, Faculty of Social Sciences, Brock University, St. Catharines, ON, Canada.
Jeffrey R GruenDepartments of Pediatrics and Genetics, Yale University School of Medicine, New Haven, CT, USA. jeffrey.gruen@yale.edu.ORCID http://orcid.org/0000-0001-7640-2071
GRaD Study Consortium

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
VALIDITY OF SUBTYPES OF ADHDP50HD027802 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI ERIK G WILLCUTT · 1990 to 2026
$44.9M
THE FLORIDA LONGITUDINAL STUDYP50HD052120 · NICHD · FLORIDA STATE UNIVERSITY · PI CHRIS W SCHATSCHNEIDER · 2006 to 2026
$31.7M
Discovery of the 6p21.3 Reading Disability GeneR01NS043530 · NINDS · YALE UNIVERSITY · PI GRUEN, JEFFREY R · 2003 to 2010
$4.3M
Analysis of Genomic and Complex DataR01HG010171 · NHGRI · YALE UNIVERSITY · PI ZHANG, HEPING · 2019 to 2022
$1.4M
NCATS NIH HHS UL1 TR001863NHGRI NIH HHS R01 HG010171NICHD NIH HHS P50 HD027802NICHD NIH HHS P50 HD052120NINDS NIH HHS R01 NS043530
6 · The paper itself

Abstract

Proficient reading requires critical phonological processing skill that interacts with both genetic and environmental factors. However, the precise nature of the relationships between phonological processing and genetic and environmental factors are poorly understood. We analyzed data from the Genes, Reading and Dyslexia (GRaD) Study on 1419 children ages 8-15 years from African-American and Hispanic-American family backgrounds living in North America. The analyses showed that phonological awareness mediated the relationship between DCDC2-READ1 and reading outcomes when parental education and socioeconomic status was low. The association between READ1 and reading performance is complex, whereby mediation by phonological awareness was significantly moderated by both parental education and socioeconomic status. These results show the importance of home environment and phonological skills when determining associations between READ1 and reading outcomes. This will be an important consideration in the development of genetic screening for risk of reading disability.

Identifiers

PMID38702345
PMCPMC11068914

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.