Evidence map›Paper›PMID 38702230›Full record

ArticleVaccine2024

Changes in depressive symptoms and antibody production following influenza vaccination in adolescents and adults.

Katherine B Ehrlich, Sarah M Lyle, Kelsey L Corallo, Justin A Lavner, Ted M Ross

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Katherine B EhrlichDepartment of Psychology, University of Georgia, Athens, GA 30602, USA; Center for Family Research, University of Georgia, Athens, GA 30602, USA. Electronic address: kehrlich@uga.edu.
Sarah M LylePsychology Discipline, Eckerd College, St. Petersburg, FL, USA.
Kelsey L CoralloGeorgia Health Policy Center, Georgia State University, Atlanta GA, USA.
Justin A LavnerDepartment of Psychology, University of Georgia, Athens, GA 30602, USA.
Ted M RossCenter for Vaccines and Immunology, University of Georgia, Athens, GA, USA; Department of Infectious Diseases, University of Georgia, Athens, GA, USA.

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
COVID Supplement - COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES,75N93019C00052 · NIAID · UNIVERSITY OF GEORGIA · PI ROSS, TED · 2019 to 2025
$74.6M
Innovative Approaches to the Study of Social Determinants of Health in ChildrenDP2MD013947 · NIMHD · UNIVERSITY OF GEORGIA · PI EHRLICH, KATHERINE BABCOCK · 2018 to 2018
$2.3M
NCATS NIH HHS UL1 TR002378NIAID NIH HHS 75N93019C00052NIMHD NIH HHS DP2 MD013947
6 · The paper itself

Abstract

objectivePsychological distress has been associated with dampened antibody production following vaccination. Questions remain, however, about whether psychological distress influences vaccine response uniformly across the lifespan, and whether changes in distress result in changes in antibody production across the same period.

methodsParticipants (N = 148; M

resultsAnalyses examined both within-season and across-season effects of depressive symptoms, age, and their interaction on vaccine response. Within-season analyses revealed that age predicted antibody response during both seasons (2017-2018 and 2018-2019). Neither depressive symptoms nor the interaction with age were associated with antibody response to vaccination within either season. Across the two seasons, age significantly moderated the association between change in depressive symptoms and change in antibody production. For people who were 48 or older, increases in depressive symptoms across the two seasons were associated with a less robust response to the vaccine in the second season relative to the first season. For people younger than 48, changes in depressive symptoms were not significantly related to changes in antibody production.

conclusionsThese findings highlight the important role of mental health for older adults' vaccine response, which could have clinical relevance for protection against disease.

Indexed as

Antibodies, ViralAntibody FormationDepressionInfluenza, HumanInfluenza VaccinesVaccinationAdolescentAdultAgedAged, 80 and overChildFemaleHumansMaleMiddle AgedSeasonsAntibodies, ViralInfluenza VaccinesAntibody response to vaccinationDepressive symptomsInfluenza vaccine

Identifiers

PMID38702230
PMCPMC11128339

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.