Evidence map›Paper›PMID 38701909›Full record

ArticleInternational journal of pharmaceutics2024

Spray drying Eudragit® E-PO with acetaminophen using 2- and 3-fluid nozzles for taste masking.

Linda A Felton, Gülşilan Binzet, Cody Wiley, David McChesney, Jason McConville, Metin Ҫelik, Pavan Muttil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linda A FeltonUniversity of New Mexico College of Pharmacy, MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: lafelton@salud.unm.edu.
Gülşilan BinzetUniversity of New Mexico College of Pharmacy, MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131, USA; Altınbaş University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Bakırköy 34147 İstanbul, Turkey. Electronic address: binzetgul@gmail.com.
Cody WileyUniversity of New Mexico College of Pharmacy, MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: cwiley@salud.unm.edu.
David McChesneyUniversity of New Mexico College of Pharmacy, MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: damcchesney@salud.unm.edu.
Jason McConvilleUniversity of New Mexico College of Pharmacy, MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: jmcconville@salud.unm.edu.
Metin ҪelikUniversity of New Mexico College of Pharmacy, MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131, USA; Pharmaceutical Technologies International, Inc., 22 Durham Rd, Skillman, NJ 08558, USA. Electronic address: metin.celik@pt-int.com.
Pavan MuttilUniversity of New Mexico College of Pharmacy, MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: pmuttil@salud.unm.edu.

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Aqueous-based Two-Step Spray Drying as a Taste Masking Drug Delivery PlatformR21HD095100 · NICHD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI FELTON, LINDA A. · 2018 to 2019
$417k
NCI NIH HHS P30 CA118100NICHD NIH HHS R21 HD095100
6 · The paper itself

Abstract

Conventional spray drying using a 2-fluid nozzle forms matrix microparticles, where drug is distributed throughout the particle and may not effectively mask taste. In contrast, spray drying using a 3-fluid nozzle has been reported to encapsulate material. The objective of this study was to spray dry Eudragit® E-PO (EE) with acetaminophen (APAP), a water-soluble model drug with a bitter taste, using 2- and 3-fluid nozzles for taste masking. Spray drying EE with APAP, however, resulted in yields of ≤ 13 %, irrespective of nozzle configuration. Yields improved when Eudragit® L 100-55 (EL) or Methocel® E6 (HPMC) was used in the inner fluid stream of the 3-fluid nozzle or in place of EE for the 2-fluid nozzle. Drug release from microparticles prepared with the 2-fluid nozzle was relatively rapid. Using EE in the outer fluid stream of the 3-fluid nozzle resulted in comparatively slower drug release, although drug release was observed, indicating that encapsulation was incomplete. Results from these studies also show that miscible polymers used in the two fluid streams mix during the spray drying process. In addition, findings from this study indicate that the polymer used in the inner fluid stream can impact drug release.

Indexed as

AcetaminophenDrug LiberationPolymethacrylic AcidsTasteAcrylic ResinsDesiccationDrug CompoundingHypromellose DerivativesParticle SizeSolubilitySpray DryingAcetaminophenAcrylic ResinsEudragit E POEudragit L100-55Hypromellose DerivativesPolymethacrylic Acids3-fluid nozzleDrug releaseEudragit ESpray dryingTaste masking

Identifiers

PMID38701909
PMCPMC11139551

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.