ArticleNeuron2024
Locus coeruleus norepinephrine contributes to visual-spatial attention by selectively enhancing perceptual sensitivity.
Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Transcutaneous Cervical Vagus Nerve Stimulation Improves Speech Comprehension in Noise: A Crossover, Placebo-Controlled Study.Neuromodulation : journal of the International Neuromodulation Society · 2025Trial
- Neurobiological influences on event perception: the role of catecholamines.The international journal of neuropsychopharmacology · 2025Trial
- Acetylcholine enhances deviance detection in Hodgkin-Huxley neuronal networks.Cognitive neurodynamics · 2026Article
- Top-down control of sustained attention by medial prefrontal cortex-locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT).Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Nurses' Visual Attention During Initial Observation of Patients With Suspected Pneumonia: An Observational Pupillometry Study.Japan journal of nursing science : JJNS · 2026Observational
- Locus coeruleus activation transforms cortical taste representations.Cell reports · 2026Article
- Regulation of the decision threshold by the locus coeruleus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Frontal theta phase modulates asymmetric posterior neural mechanisms of spatial attention.bioRxiv : the preprint server for biology · 2026Article
- Locus coeruleus modulation of neurophysiological sensory selectivity differs in autism and other mental health conditions.Translational psychiatry · 2026Article
- Rapid dynamics of dorsal raphe serotonin neurons regulate the strength of visual attention.Nature communications · 2026Article
- The role of the locus coeruleus in eye movements during perceptual decision making.bioRxiv : the preprint server for biology · 2026Article
- Pupil dilation as a marker of attention/effort in aging and mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Attention-related modulation in the superior colliculus encodes perceptual sensitivity, but not perceptual choice.Nature communications · 2026Article
- The Contribution of the Locus Ceruleus-Norepinephrine System to the Coupling between Pupil-Linked Arousal and Cortical State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Behavioral state-dependent norepinephrine dynamics in the primary somatosensory and prefrontal cortices during tactile detection tasks.bioRxiv : the preprint server for biology · 2026Article
- Reduced volume of neuromodulatory brainstem nuclei is associated with early hallucination-related vulnerability in Parkinson's disease.Brain communications · 2026Article
- Top-down control of sustained attention by the medial prefrontal cortex (mPFC) - locus coeruleus (LC) circuit during the rodent continuous performance test (rCPT).bioRxiv : the preprint server for biology · 2025Article
- Eye movement evidence for locus coeruleus-noradrenaline system contributions to age differences in attention.Psychology and aging · 2025Article
- Long-term Locus Coeruleus Stimulation Exacerbates Tau Pathology in PS19 Mice.bioRxiv : the preprint server for biology · 2025Article
- Low affinity noradrenergic signaling promotes passive coping during reinforcement behavior.bioRxiv : the preprint server for biology · 2025Article
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2 authors.
Funding
Abstract
Selectively focusing on a behaviorally relevant stimulus while ignoring irrelevant stimuli improves perception. Enhanced neuronal response gain is thought to support attention-related improvements in detection and discrimination. However, understanding of the neuronal pathways regulating perceptual sensitivity remains limited. Here, we report that responses of norepinephrine (NE) neurons in the locus coeruleus (LC) of non-human primates to behaviorally relevant sensory stimuli promote visual discrimination in a spatially selective way. LC-NE neurons spike in response to a visual stimulus appearing in the contralateral hemifield only when that stimulus is attended. This spiking is associated with enhanced behavioral sensitivity, is independent of motor control, and is absent on error trials. Furthermore, optogenetically activating LC-NE neurons selectively improves monkeys' contralateral stimulus detection without affecting motor criteria, supporting NE's causal role in granular cognitive control of selective attention at a cellular level, beyond its known diffuse and non-selective functions.
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