Evidence map›Paper›PMID 38701395›Full record

ArticleHepatology communications2024

PHES scores have limited impact on the risk of overt HE in patients with minimal HE.

Simon Johannes Gairing, Chiara Mangini, Lisa Zarantonello, Elise Jonasson, Sven Danneberg, Philippe Sultanik, Peter Robert Galle, Stefania Gioia, Joachim Labenz, Anna S Lok and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hepatology communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Simon Johannes GairingDepartment of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.ORCID 0000-0003-3240-5152
Chiara ManginiDepartment of Medicine, University of Padova, Padova, Italy.
Lisa ZarantonelloDepartment of Medicine, University of Padova, Padova, Italy.
Elise JonassonDepartment of Gastroenterology and Hepatology, Hospital of South West Jutland, Esbjerg, Denmark.
Sven DannebergDepartment of Medicine I, University Hospital Schleswig-Holstein, Lübeck, Germany.
Philippe SultanikService d'hépato-gastroentérologie, Sorbonne Université, Hôpital Pitié-Salpêtrière Assistance Publique Hôpitaux de Paris, Paris, France.
Peter Robert GalleDepartment of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Stefania GioiaDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Joachim LabenzDepartment of Medicine, Diakonie Hospital Jung-Stilling, Siegen, Germany.
Anna S LokDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.
Jens Uwe MarquardtDepartment of Medicine I, University Hospital Schleswig-Holstein, Lübeck, Germany.
Mette Munk LauridsenDepartment of Gastroenterology and Hepatology, Hospital of South West Jutland, Esbjerg, Denmark.
Patricia P BloomDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.
Dominique ThabutService d'hépato-gastroentérologie, Sorbonne Université, Hôpital Pitié-Salpêtrière Assistance Publique Hôpitaux de Paris, Paris, France.
Silvia NardelliDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Sara MontagneseDepartment of Medicine, University of Padova, Padova, Italy.
Christian LabenzDepartment of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.ORCID 0000-0001-8390-9663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMinimal hepatic encephalopathy, defined by the portosystemic hepatic encephalopathy score (PHES), is associated with a higher risk of subsequent OHE. It remains unclear if there is a stepwise increase in OHE risk with worse PHES results.

methodsIn this multicenter study, patients with minimal hepatic encephalopathy, as defined by abnormal PHES, were followed for OHE development.

resultsIn all, 207 patients were included. There was no stepwise increase in OHE risk with worse PHES results.

conclusionsAbnormal PHES is associated with a higher OHE risk, but we found no stepwise increase in OHE risk with worse PHES results below the established cutoff.

Indexed as

Hepatic EncephalopathyAdultAgedFemaleHumansMaleMiddle AgedRisk AssessmentRisk FactorsSeverity of Illness Index

Identifiers

PMID38701395
PMCPMC11073767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.