Evidence map›Paper›PMID 38701349›Full record

ArticleJournal of the American Chemical Society2024

Unnatural Peptide Assemblies Rapidly Deplete Cholesterol and Potently Inhibit Cancer Cells.

Qiuxin Zhang, Weiyi Tan, Zhiyu Liu, Yichi Zhang, Wei-Shao Wei, Seth Fraden, Bing Xu

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment.Angewandte Chemie (International ed. in English) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiuxin ZhangDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.ORCID 0000-0002-8659-3569
Weiyi TanDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.ORCID 0000-0001-5316-8278
Zhiyu LiuDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.
Yichi ZhangDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.
Wei-Shao WeiMartin A. Fisher School of Physics, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.
Seth FradenMartin A. Fisher School of Physics, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.
Bing XuDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.ORCID 0000-0002-4639-387X

Funding

Subcellular Enzyme-instructed self-assembly for molecular anticancer nanomedicinesR01CA142746 · NCI · BRANDEIS UNIVERSITY · PI Bing Xu · 2010 to 2026
$6.4M
A 400 MHz NMR SpectrometerS10OD034395 · OD · BRANDEIS UNIVERSITY · PI KRAUSS, ISAAC JONATHAN · 2023 to 2023
$482k
Exploring enzyme-instructed self-assembly (EISA) for targeting osteoblastic metastasis of prostate cancerR21CA252364 · NCI · BRANDEIS UNIVERSITY · PI HSIEH, JER-TSONG, XU, BING · 2020 to 2020
$430k
NCI NIH HHS R01 CA142746NCI NIH HHS R21 CA252364NIH HHS S10 OD034395
6 · The paper itself

Abstract

Cholesterol-rich membranes play a pivotal role in cancer initiation and progression, necessitating innovative approaches to target these membranes for cancer inhibition. Here we report the first case of unnatural peptide (

Indexed as

CholesterolPeptidesAntineoplastic AgentsCell Line, TumorCell MembraneCell ProliferationHumansAntineoplastic AgentsCholesterolPeptides

Identifiers

PMID38701349
PMCPMC11223060

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.