Evidence map›Paper›PMID 38701119›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology.

Chandrashekhar Madasu, Zian Liao, Sydney E Parks, Kiran L Sharma, Kurt M Bohren, Qiuji Ye, Feng Li, Murugesan Palaniappan, Zhi Tan, Fei Yuan and 7 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Identification of potent inhibitors of JUN N-terminal kinases for treatment of endometriosis and associated pain.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. The long road of drug development for endometriosis - Pains, gains, and hopes.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Review
  11. Review
  12. Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Deciphering the code: Advancing therapies for endometriosis and cancer with DNA-encoded drug discovery.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Chandrashekhar Madasu *Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.
Zian Liao *Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-7198-2182
Sydney E ParksDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.
Kiran L SharmaDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-1988-389X
Kurt M BohrenDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-3183-4118
Qiuji YeDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-3812-3001
Feng LiDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-9680-4614
Murugesan PalaniappanDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0003-4916-6565
Zhi TanDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.
Fei YuanDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.
Chad J CreightonDan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030.
Suni TangDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.
Ramya P MasandDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.
Xiaoming GuanDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030.
Damian W YoungDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.
Diana MonsivaisDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.
Martin M MatzukDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-1445-8632

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Kinases as Therapeutic Targets for EndometriosisR01HD110038 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2022 to 2026
$3.4M
Targeting the endometrial stem cell niche inendometriosisR01HD105800 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Diana Monsivais · 2022 to 2026
$2.5M
Elucidating Chemical Features that Block or Facilitate Passage across the Blood-Testis and/or Blood-Epidydimal Barriers in MiceR33HD099995 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LI, FENG · 2022 to 2024
$1.7M
The role of SMAD1 and SMAD5 in hormonal response, endometrial receptivity and glandular functionR00HD096057 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MONSIVAIS, DIANA · 2020 to 2022
$728k
The role of SMAD1 and SMAD5 in hormonal response, endometrial receptivity and glandular functionK99HD096057 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MONSIVAIS, DIANA · 2018 to 2019
$260k
Development of a Precision Drug to target Y537S Mutant Estrogen Receptor in Metastatic Breast CancerR03CA259664 · NCI · BAYLOR COLLEGE OF MEDICINE · PI PALANIAPPAN, MURUGESAN · 2022 to 2023
$160k
NCI NIH HHS P30 CA125123NCI NIH HHS R03 CA259664NICHD NIH HHS K99 HD096057NICHD NIH HHS R00 HD096057NICHD NIH HHS R01 HD105800NICHD NIH HHS R01 HD110038NICHD NIH HHS R33 HD099995
6 · The paper itself

Abstract

EPH receptors (EPHs), the largest family of tyrosine kinases, phosphorylate downstream substrates upon binding of ephrin cell surface-associated ligands. In a large cohort of endometriotic lesions from individuals with endometriosis, we found that

Indexed as

Protein Kinase InhibitorsCell MovementDNAEndometriosisFemaleHumansReceptor, EphA2Receptors, Eph FamilySmall Molecule LibrariesDNAProtein Kinase InhibitorsReceptor, EphA2Receptors, Eph FamilySmall Molecule LibrariesDNA-encoded chemistryendometriosisephrin receptor kinase inhibitors

Identifiers

PMID38701119
PMCPMC11087803

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.