Evidence map›Paper›PMID 38700819›Full record

ReviewThe international journal of cardiovascular imaging2024

Artificial intelligence in coronary artery calcium score: rationale, different approaches, and outcomes.

Antonio G Gennari, Alexia Rossi, Carlo N De Cecco, Marly van Assen, Thomas Sartoretti, Andreas A Giannopoulos, Moritz Schwyzer, Martin W Huellner, Michael Messerli

Abstract readReview
In one paragraph

Review in The international journal of cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Opportunistic Screening on Chest CT, From theAJR. American journal of roentgenology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Antonio G GennariDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland.ORCID http://orcid.org/0000-0003-2224-0083
Alexia RossiDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland.ORCID http://orcid.org/0000-0001-6845-1199
Carlo N De CeccoDivision of Cardiothoracic Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-2956-3101
Marly van AssenTranslational Laboratory for Cardiothoracic Imaging and Artificial Intelligence, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-4044-4426
Thomas SartorettiDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland.ORCID http://orcid.org/0000-0002-4812-987X
Andreas A GiannopoulosDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland.ORCID http://orcid.org/0000-0002-0938-3170
Moritz SchwyzerDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland.ORCID http://orcid.org/0000-0002-9095-032X
Martin W HuellnerDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland.ORCID http://orcid.org/0000-0002-4849-3292
Michael MesserliDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland. michael.messerli@usz.ch.ORCID http://orcid.org/0000-0001-7815-3048

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Almost 35 years after its introduction, coronary artery calcium score (CACS) not only survived technological advances but became one of the cornerstones of contemporary cardiovascular imaging. Its simplicity and quantitative nature established it as one of the most robust approaches for atherosclerotic cardiovascular disease risk stratification in primary prevention and a powerful tool to guide therapeutic choices. Groundbreaking advances in computational models and computer power translated into a surge of artificial intelligence (AI)-based approaches directly or indirectly linked to CACS analysis. This review aims to provide essential knowledge on the AI-based techniques currently applied to CACS, setting the stage for a holistic analysis of the use of these techniques in coronary artery calcium imaging. While the focus of the review will be detailing the evidence, strengths, and limitations of end-to-end CACS algorithms in electrocardiography-gated and non-gated scans, the current role of deep-learning image reconstructions, segmentation techniques, and combined applications such as simultaneous coronary artery calcium and pulmonary nodule segmentation, will also be discussed.

Indexed as

Coronary AngiographyCoronary Artery DiseaseCoronary VesselsDeep LearningPredictive Value of TestsRadiographic Image Interpretation, Computer-AssistedVascular CalcificationArtificial IntelligenceCardiac-Gated Imaging TechniquesComputed Tomography AngiographyHumansPrognosisReproducibility of ResultsSeverity of Illness IndexArtificial intelligenceComputed tomographyCoronary artery calciumCoronary artery calcium scoreDeep-learningMachine learning

Identifiers

PMID38700819
PMCPMC11147943

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.