Evidence map›Paper›PMID 38700804›Full record

ArticleMikrochimica acta2024

Micropump integrated white blood cell separation platform for detection of chronic granulomatous disease.

Sanjay Mane, Abhishek Behera, Vadiraj Hemadri, Sunil Bhand, Siddhartha Tripathi

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sanjay ManeDepartment of Mechanical Engineering, BITS-Pilani, K K Birla Goa Campus, Sankval, Goa, 403726, India.
Abhishek BeheraDepartment of Mechanical Engineering, BITS-Pilani, K K Birla Goa Campus, Sankval, Goa, 403726, India.
Vadiraj HemadriDepartment of Mechanical Engineering, BITS-Pilani, K K Birla Goa Campus, Sankval, Goa, 403726, India.
Sunil BhandDepartment of Chemistry, BITS-Pilani, K K Birla Goa Campus, Sankval, Goa, 403726, India.
Siddhartha TripathiDepartment of Mechanical Engineering, BITS-Pilani, K K Birla Goa Campus, Sankval, Goa, 403726, India. siddharthat@goa.bits-pilani.ac.in.

Funding

BITS BioCyTiH foundation covered by National Mission for Interdisciplinary - Cyber Physical System (NM-ICPS) of Department of Science and Technology, Government of India BBF/BITS (G)/FY2022-23/BCPS-115
6 · The paper itself

Abstract

White blood cells (WBCs) are robust defenders during antigenic challenges and prime immune cell functioning indicators. High-purity WBC separation is vital for various clinical assays and disease diagnosis. Red blood cells (RBCs) are a major hindrance in WBC separation, constituting 1000 times the WBC population. The study showcases a low-cost micropump integrated microfluidic platform to provide highly purified WBCs for point-of-care testing. An integrated user-friendly microfluidic platform was designed to separate WBCs from finger-prick blood (⁓5 μL), employing an inertial focusing technique. We achieved an efficient WBC separation with 86% WBC purity and 99.99% RBC removal rate in less than 1 min. In addition, the microdevice allows lab-on-chip colorimetric evaluation of chronic granulomatous disease (CGD), a rare genetic disorder affecting globally. The assay duration, straight from separation to disease detection, requires only 20 min. Hence, the proposed microfluidic platform can further be implemented to streamline various clinical procedures involving WBCs in healthcare industries.

Indexed as

Cell SeparationGranulomatous Disease, ChronicLab-On-A-Chip DevicesLeukocytesMicrofluidic Analytical TechniquesHumansCGDInertial focusingLab-on-chipMicropumpWBCs

Identifiers

PMID38700804

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.