ArticleBiomechanics and modeling in mechanobiology2024
An in silico approach to elucidate the pathways leading to primary osteoporosis: age-related vs. postmenopausal.
Article in Biomechanics and modeling in mechanobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- The interrelationship between calcium-phosphorus homeostasis and bone remodelling. Impact of dietary changes on bone in patients with primary hyperparathyroidism and chronic kidney disease.Frontiers in bioengineering and biotechnology · 2026Article
- Analysis of influencing factors and predictive performance of lumbar disc herniation in elderly patients with osteoporosis.Frontiers in endocrinology · 2026Article
- Mathematical modeling of bone remodeling after surgical menopause.Frontiers in systems biology · 2026Article
- Computational simulations of endocrine bone diseases related to pathological glandular PTH secretion using a multi-scale bone cell population model.Frontiers in bioengineering and biotechnology · 2025Article
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5 authors.
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Abstract
Numerical models of bone remodelling have traditionally been used to perform in silico tests of bone loss in postmenopausal women and also to simulate the response to different drug treatments. These models simulate the menopausal oestrogen decline by altering certain signalling pathways. However, they do not consider the simultaneous effect that ageing can have on cell function and bone remodelling, and thus on bone loss. Considering ageing and oestrogen decline together is important for designing osteoporosis treatments that can selectively counteract one or the other disease mechanism. A previously developed bone cell population model was adapted to consider the effect of ageing through: (1) the decrease of TGF-
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