Evidence map›Paper›PMID 38700762›Full record

ReviewProbiotics and antimicrobial proteins2024

What We Know About the Actual Role of Traditional Probiotics in Health and Disease.

Faisal Al-Akayleh, Ahmed S A Ali Agha, Mayyas Al-Remawi, Ibrahim S I Al-Adham, Saifeddin Daadoue, Anagheem Alsisan, Dana Khattab, Doha Malath, Haneen Salameh, Maya Al-Betar and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Probiotics and antimicrobial proteins, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Molecular Mechanisms of Probiotic Action Against Gastrointestinal Cancers.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Faisal Al-AkaylehFaculty of Pharmacy & Medical Sciences, University of Petra, Amman, 11196, Jordan. falakayleh@uop.edu.jo.
Ahmed S A Ali AghaFaculty of Pharmacy & Medical Sciences, University of Petra, Amman, 11196, Jordan.
Mayyas Al-RemawiFaculty of Pharmacy & Medical Sciences, University of Petra, Amman, 11196, Jordan.
Ibrahim S I Al-AdhamFaculty of Pharmacy & Medical Sciences, University of Petra, Amman, 11196, Jordan.
Saifeddin DaadoueFaculty of Pharmacy & Medical Sciences, University of Petra, Amman, 11196, Jordan.
Anagheem AlsisanFaculty of Pharmacy & Medical Sciences, University of Petra, Amman, 11196, Jordan.
Dana KhattabFaculty of Pharmacy & Medical Sciences, University of Petra, Amman, 11196, Jordan.
Doha MalathFaculty of Pharmacy & Medical Sciences, University of Petra, Amman, 11196, Jordan.
Haneen SalamehFaculty of Pharmacy & Medical Sciences, University of Petra, Amman, 11196, Jordan.
Maya Al-BetarFaculty of Pharmacy & Medical Sciences, University of Petra, Amman, 11196, Jordan.
Motaz AlSakkaFaculty of Pharmacy & Medical Sciences, University of Petra, Amman, 11196, Jordan.
Phillip J CollierFaculty of Pharmacy & Medical Sciences, University of Petra, Amman, 11196, Jordan. pip.collier@yahoo.com.ORCID 0000-0001-8529-2548

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complex relationship between probiotics and human health goes beyond their traditional function in gut health, generating considerable interest for their broad potential in disease treatment. This review explores the various functions of probiotics, highlighting their impact on the immune system, their benefits for gut and oral health, their effects on metabolic and neurological disorders, and their emerging potential in cancer therapy. We give significant importance to studying the effects of probiotics on the gut-brain axis, revealing new and non-invasive therapeutic approaches for complex neurological disorders. In addition, we expand the discussion to encompass the impact of probiotics on the gut-liver and gut-lung axes, recognizing their systemic effects and potential in treating respiratory and hepatic conditions. The use of probiotic "cocktails" to improve cancer immunotherapy outcomes indicates a revolutionary approach to oncological treatments. The review explores the specific benefits associated with various strains and the genetic mechanisms that underlie them. This study sets the stage for precision medicine, where probiotic treatments can be tailored to meet the unique needs of each patient. Recent developments in delivery technologies, including microencapsulation and nanotechnology, hold great potential for enhancing the effectiveness and accuracy of probiotic applications in therapeutic settings. This study provides a strong basis for future scientific research and clinical use, promoting the incorporation of probiotics into treatment plans for a wide range of diseases. This expands our understanding of the potential benefits of probiotics in modern medicine.

Indexed as

ProbioticsAnimalsGastrointestinal MicrobiomeHumansNeoplasmsNervous System DiseasesCancer treatmentDiabetesNeurological disordersProbioticsStrain-specific

Identifiers

PMID38700762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.