Evidence map›Paper›PMID 38700599›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Serum neurofilament light chain levels correlate with small fiber related parameters in patients with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN).

Eleonora Galosi, Rocco Costanzo, Francesca Forcina, Stefania Morino, Giovanni Antonini, Marco Salvetti, Antonio Lauletta, Marco Luigetti, Angela Romano, Guido Primiano and 8 more

Abstract read

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

Disease Prognosis and Progression in Transthyretin Amyloidosis: JACC: CardioOncology State-of-the-Art Review.JACC. CardioOncology · 2026
Review
Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Biomarkers in Hereditary Transthyretin Amyloidosis Polyneuropathy.Journal of the peripheral nervous system : JPNS · 2026
Article
Exploratory Evaluation of the Predictive Value of Serum Neurofilament Light Chain for Autonomic Neuropathy in Hereditary Transthyretin Amyloidosis.Journal of clinical medicine · 2026
Article
Comparative Analysis of Small Nerve Fiber Density in Fibromyalgia Syndrome and Small Fiber Neuropathy.Biomedicines · 2025
Article
NfL as a biomarker in ATTRv amyloidosis: potential and limitations.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
Article
Comparative Analysis of SiMoA and Ella Immunoassay Platforms for Measuring Serum Neurofilament Light Chain Levels in ATTRv With Polyneuropathy and Presymptomatic Carriers.European journal of neurology · 2025
Article
Elevated serum concentrations of GFAP in hereditary transthyretin amyloidosis since pre-symptomatic stages.Journal of neurology · 2025
Article
Early nociceptive evoked potentials in symptomatic and asymptomatic transthyretin mutation carriers.Frontiers in neurology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Eleonora GalosiDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy. eleonora.galosi@uniroma1.it.ORCID http://orcid.org/0000-0002-4464-9982

Rocco CostanzoDepartment of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.

Francesca ForcinaDepartment of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.

Stefania MorinoDepartment of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.

Giovanni AntoniniDepartment of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.

Marco SalvettiDepartment of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.

Antonio LaulettaDepartment of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.

Marco LuigettiFondazione Policlinico Universitario A, Gemelli IRCCS, UOC Neurologia, Rome, Italy.

Angela RomanoFondazione Policlinico Universitario A, Gemelli IRCCS, UOC Neurologia, Rome, Italy.

Guido PrimianoFondazione Policlinico Universitario A, Gemelli IRCCS, UOC Neurologia, Rome, Italy.

Valeria GuglielminoDipartimento Di Neuroscienze, Università Cattolica del Sacro Cuore, Sede Di Roma, Rome, Italy.

Laura FiondaDepartment of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.

Matteo GaribaldiDepartment of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.

Nicoletta EspositoDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.

Pietro FalcoDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.

Giuseppe di PietroDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.

Andrea TruiniDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.

Luca LeonardiDepartment of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.

Funding

Ministero della Salute GR-2021-12372306

6 · The paper itself

Abstract

backgroundRecent evidence suggests that both serum neurofilament light chain (sNfL) levels and small fiber related diagnostic variables may be valuable disease biomarkers of hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN). Our study aimed to explore the relations between sNfL and small fiber related skin biopsy and quantitative sensory testing (QST) parameters in a cohort of ATTRv-PN patients and pre-symptomatic carriers.

methodsWe retrospectively analyzed data from 13 ATTRv patients and 21 pre-symptomatic carriers who underwent sNfL dosage, skin biopsy, and QST, and analyzed correlations between sNFL, intraepidermal nerve fiber density (IENFD), and cold (CDT) and warm detection thresholds (WDT).

resultsBoth sNfL and small fiber related parameters significantly differed between carriers and patients (sNfL: p < 0.0001; IENFD: p = 0.0008; CDT, WDT: < 0.0001). sNFL levels were normal in all carriers, altered in 85% of patients, negatively correlated with distal IENFD (r = -0.47, p = 0.005), and significantly correlated with CDT (r = -0.68; p < 0.0001) and WDT (r = 0.57; p < 0.0001).

conclusionsOur study showed that sNfL reliably discriminates symptomatic ATTRv-PN patients from pre-symptomatic carriers, and found significant relations between sNfL, skin biopsy, and QST small fiber related parameters, suggesting that sNfL might be a valuable biomarker of peripheral nerve involvement in ATTRv-PN and a supportive criterion for symptomatic disease transition.

Indexed as

Amyloid Neuropathies, FamilialNeurofilament ProteinsAdultAgedBiomarkersFemaleHumansMaleMiddle AgedNerve FibersPolyneuropathiesRetrospective StudiesSkinBiomarkersneurofilament protein LNeurofilament ProteinsHereditary transthyretin amyloidosis (ATTRv)Quantitative sensory testingSerum neurofilaments light chainSkin biopsySmall fiber neuropathy

Identifiers

PMID38700599

DOI10.1007/s10072-024-07562-0

PMCPMC11422273

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.